Use of 3-N-phenylacetylamino-2,6-piperidinedione for treatment o

Details Use of 3-N-phenylacetylamino-2,6-piperidinedione for treatment o Use of 3-N-phenylacetylamino-2,6-piperidinedione for treatment o

1986-08-25

1987-11-10

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31445

Patent

active

047057963

ABSTRACT:
Composition of 3-N-phenylacetylamino-2,6-piperdinedione is disclosed as useful in the treatment of neuropsychiatric disorders involving monoamine oxidase regulation. 3-N-phenylacetylamino-2,6-piperidinedione has been shown to be an effective and selective MAO type B inhibitor.

REFERENCES:
patent: 4470970 (1984-09-01), Burzynski
patent: 4558057 (1985-12-01), Burzynski
Burzynski et al., "Human Toxicology Studies on Oral Formulation of Antineoplaston A10" (Drugs Exptl. Clin. Res. 891-909, 1984).
Diamond et al., "Differentiation of Phenylethylamine (PE)-and Amphetamine (AMPH)-Induced Behaviors" (Neurobiology of the Trace Amines 375-388, 1984).
Ortmann et al., "Phenylethylamine-Induced Stereotypes in the Rat: a Behavioral Test System for Assessment of MAO-B Inhibitors" (Psychopharmacology 84:22-27.
Johnston, "Some Observations Upon a New Inhibitor of Monoamine Oxidase in Brain Tissue" (Biochemical Pharmacology 17:1285-1297, 1968).
Birkmayer et al., "Deprenyl Prolongs the Therapeutic Efficacy of Combined L-DOPA in Parkinson's Disease" (Advances in Neurology 40:475-481, 1984).
Diamond et al., "Neuropeptides and other Dopamine Modulators in the Extrapyramidal System" (Catecholamines: Basic & Clinical Frontiers 1620-1622, 1979).

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