Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1991-08-14
1992-07-28
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514557, 514634, A61K 31195, A61K 3119, A61K 31155
Patent
active
051341646
ABSTRACT:
The present invention provides a method for treating or preventing certain metabolic disorders comprising the systemic administration of 3-guanidinopropionic acid.
REFERENCES:
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F. Blachier, et al., "Stimulus-Secretion Coupling of Arginine-Induced Insulin Release. Uptake of Metabolized and Nonmetabolized Cationic Amino Acids by Pancreatic Islets", Endocrinology 124:134-141 (1989).
J. J. Roberts and J. B. Walker, "Feeding a Creatine Analogue Delays ATP Depletion and Onset of Rigor in Ischemic Heart", Am. J. Physiol. 243:H911-H916 (1982).
T. S. Moerland, et al., "Administration of a Creatine Analogue Induces Isomyosin Transitions in Muscle", Am. J. Physiol. 257:C810-C816 (1989).
E. A. Shoubridge, et al., "Biochemical Adaptation in the Skeletal Muscle of Rats Depleted of Creatine with the Substrate Analogue .beta.-Guanidinopropionic Acid", Biochem. J. 232:125-131 (1985).
D. A. Mahanna, et al., "Effects of .beta.-Guanidinopropionic Acid on Murine Skeletal Muscle", Exper. Neurol. 68:114-121 (1980).
R. P. Shields, et al., "Skeletal Muscle Function and Structure after Depletion of Creatine", Lab. Invest. 33:151-158 (1975).
The Upjohn Company
Waddell Frederick E.
Weddington K.
Welch Lawrence T.
Wright Debbie K.
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