Use of 3-guanidinopropionic acid in the treatment and prevention

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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Details

514565, 514634, A61K 3119, A61K 31195, A61K 31155

Patent

active

055998410

ABSTRACT:
The present invention provides a method for treating or preventing certain metabolic disorders comprising the systemic administration of 3-guanidinopropionic acid.

REFERENCES:
patent: 3843798 (1974-10-01), Cook
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E. A. Shoubridge, et al., "Biochemical Adaptation in the Skeletal Muscle of Rats Depleted of Creatine with the Substrate Analogue .beta.-Guanidinopropionic Acid", Biochem. J. 232:125-131 (1985).
D. A. MaHanna, et al., "Effects of .beta.-Guanidinopropionic Acid on Murine Skeletal Muscle", Exper. Neurol. 68:114-121 (1980).
R. P. Shields, et al., "Skeletal Muscle Function and Structure After Depletion of Creatine", Lab. Invest. 33(2):151-158 (1975.
J. V. Otten, et al., "Thyrotoxic Myopathy in Mice: Accentuation by a Cratine Transport Inhibitor", Metabolism 35(6):481-484 (1986).
D. S. Grosso, et al., "Characterization of a Carrier-Medicated Transport System for Taurine in the Feta Mouse Heart In Vitro", J. Clin. Invest., E61(4):944-952 (1978).

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