Use of 3,4-diphenyl chromans for the manufacture of a pharmaceut

Details Use of 3,4-diphenyl chromans for the manufacture of a pharmaceut Use of 3,4-diphenyl chromans for the manufacture of a pharmaceut

1997-03-04

1999-07-06

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514428, 514456, 514874, A61K 3140

Patent

active

059198125

ABSTRACT:
The present invention provides novel uses of compounds of general formula I ##STR1## wherein R1, R4 and R5 are individually hydrogen, hydroxy, halogen, trifluoromethyl, lower alkyl, lower alkoxy or (tertiary amino)(lower alkoxy); and R2 and R3 are individually hydrogen or lower alkyl, or as a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier for the manufacture of a pharmaceutical composition for the treatment or prophylaxis of idiopathic or physiologic gynaecomastia.

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patent: 5364847 (1994-11-01), Labrie et al.
Srivasta et al., "Mode of Action Of Centchroman At Vaginal And Ovarian Level In Immature Rats", Ind. J. Physiol. Pharmac, Jan.-Mar., 1980, vol. 24, pp. 44-48.
Black et al., "Raloxifene (LY139481 HCI) Prevents Bone Loss and Reduces Serum Cholesterol Without Causing Uterine Hypertrophy In Ovariectomized Rats", J. Clin. Invest., vol. 93, Jan. 1994, pp. 63-69.
Singh, MM, et al., Acta Endocrinologica, vol. 126, pp. 444-450, (1992).

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