Use of 2-substituted benzimidazole as smooth muscle cell prolife

Details Use of 2-substituted benzimidazole as smooth muscle cell prolife Use of 2-substituted benzimidazole as smooth muscle cell prolife

1996-12-06

1998-06-09

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31415

Patent

active

057634734

ABSTRACT:
The use of compounds of the formula: ##STR1## where R.sub.1 is alkyl, trifluoromethyl or pyridinyl;
R.sub.2 is H, alkyl or substituted arylalkyl, in which the substituents are one or two halogens, carboxyl or alkoxycarbonyl groups;
R.sub.3 and R4 are H, alkyl, halogen or nitro;
or a pharmaceutically acceptable salt thereof, as inhibitors of smooth muscle cell proliferation.

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Schwartz et al. JACC, 20(5): 1284-93, Nov. 1992.
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Thomas et al. "New Nonpeptide Angiotensis II Receptor Antagonists . . . ", J. Med. Chem. 1992, 35, 877-885.
Murray et al. "Inhibition of Rat Hepatic Microsomal Aminopyridine N-Demethylase Activity by Benzimidazol Derivatives. Quantitative Structure-Activity Relationships", J. Med. Chem., 25, 887-892 (1982).

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