Use of 2-deoxystreptamine as a molecular scaffold for the prepar

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai

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514548, 514579, 514616, 560115, 560251, 564153, 564158, 564159, 564461, A61K 31133, A61K 3116, C07C21752

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06140361&

ABSTRACT:
2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.

REFERENCES:
patent: 3828021 (1974-08-01), Beattie et al.
patent: 3872080 (1975-03-01), Daniels
patent: 4218561 (1980-08-01), Paulsen et al.
patent: 4396609 (1983-08-01), Daum et al.
patent: 5288514 (1994-02-01), Ellman
patent: 5496938 (1996-03-01), Gold et al.
patent: 5534408 (1996-07-01), Green et al.
patent: 5565324 (1996-10-01), Still et al.
Hanessian et al., Can. J. Chem., vol. 56, p.1482-1491, 1978.
Goda et al., Chemical Abstracts, vol. 117, abstract 151254, 19992.
Georgiadis et al., Chemical Abstracts, vol. 116, abstract 42009, 19992.
Hichens et al., Chemical Abstracts, vol. 80, abstract 13580, 1974.
Kawaguchi et al. Chemical Abstracts, vol. 78, abstract 84748, 1973.
A. Canas-Rodriguez et al., Carbohydrate Research, 68:43-53, 1979.
R.C. Pandey et al., J. of Chromatography, 170:498-501, 1979.
M.L. Zapp et al., Cell, 74:969-978, 1993.
Tamura et al, CA, 109:231413, 1988.
E. Voss et al, CA, 95:25529d, 1981.
A.H. Khan et al, CA, 110:113298, 1988.
D.M.Barends et al, CA, 96: 14880, 1981.
S. Hanessian et al, CA, 89:215683, 1978.
A.K. Mallams, CA, 81:13755, 1974.
S. Umezawa et al, CA, 70: 58219q, 1968.
S. Umezawa et al, CA, 62:2819h, 1965.

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