Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfuco

Details Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfuco Use of 2-deoxyribose-5-phosphate aldolase to prepare 2-deoxyfuco

1995-04-05

1998-08-18

Prats, Francisco C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 72, 435130, 536 111, 536 187, 536124, C12P 1902, C12P 1100, C12P 1900, C07H 100

Patent

active

057957495

ABSTRACT:
Processes using 2-deoxyribose-5-phosphate aldolase (DERA) are described for the preparation of 2-deoxyfucose and related compounds. In one embodiment, DERA is used to catalyze the condensation of acetaldehyde as donor and a 2(R)-hydroxy-3-(hydroxy or mercapto)-propionaldehyde derivative to form a 2-deoxysugar whose hydroxyls have the configuration of fucose. In another embodiment, DERA is used to catalyze the condensation of two moles of acetaldehyde as donor and one mole of a 2-substituted acetaldehyde acceptor to form a 2,4,6-trideoxyhexose via a 4-substituted-3-hydroxybutanal intermediate.

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