Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-02-16
2004-01-27
Travers, Russell (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
Reexamination Certificate
active
06683084
ABSTRACT:
This invention relates to treatment of infection caused by human herpesvirus 6 (HHV-6), and to the use of compounds in the preparation of a medicament for use in the treatment of such conditions.
When used herein, ‘treatment’ includes prophylaxis as appropriate.
EP-A-141927 (Beecham Group p.l.c.) discloses penciclovir, the compound of formula (A):
and salts, phosphate esters and acyl derivatives thereof, as antiviral agents. The sodium salt hydrate of penciclovir is disclosed in EP-A-216459 (Beecham Group p.l.c.). Penciclovir and its antiviral activity is also disclosed in Abstract P.V11-5 p. 193 of ‘Abstracts of 14th Int. Congress of Microbiology’, Manchester, England Sep. 7-13, 1986 (Boyd et. al.).
REFERENCES:
patent: 0 141 927 (1985-05-01), None
patent: 0 182 024 (1986-05-01), None
patent: 0 216 459 (1987-07-01), None
patent: 0 458 363 (1991-11-01), None
patent: WO A 9200742 (1992-01-01), None
Harden et al., 110CA:173658P (1989).
Fields Virology 3rd Ed. BnN. Field Ed. Hippincott Phildelphia, 1996, p. 2221.
Akesson-Johansson et al. Antimicrobial Agents and Chemotherapy, Dec. 1990, pp. 2417-2419.
Lui et al. Antiviral Chemistry & Chemotherapy (1990) 1(5), pp. 313-318.
Agut et al. Institut Pasteur/Elsevier, (1989) 140(3), pp. 219-228.
Zahler, et al. Abstract EP 0, 458, 363.
Nicholas, Journal of Virology, 79(9), pp. 5975-5989 (1996).
Berneman et al., Proc. Natl. Acad. Sci., USA, 89, pp. 10552-10556 (1992).
Frenkel et al., Fields Virology, “Human Herpevirus 7”, 3rd. Ed. pp. 20609-20622 (1996).
Harnden et al., J. Chem. Soc. Perkin Trans. I (1988) 10, pp 2777084.
Boyd et al., Antiviral Chem. Chemotherapy, Suppl. 4(1), pp. 3-11 (1993).
Abashi D.V. et al. In Vivo, vol. 5(3), 1991, pp. 193-200.
J.B. Black et al., Virus Research 52 (1997) pp. 25-41.
Vere Hodge RA. et al., Antiviral Chemistry and Chemotherapy (1993) 4 Suppl. 1, pp. 13-24.
Earnshaw D.L. et al., Antimicrobial Agents and Chemotherapy (1992) 36, pp. 2747-2757.
Vere Hodge et al., Antimicrobial Agents and Chemotherapy (1989) 33, pp. 223-229.
Boyd et al., Antimicrobial Agents and Chemotherapy (1987) 31, pp. 1238-1242.
Larsson A. et al, Antimicrobial Agents and Chemotherapy (1986) 30. pp. 598-605.
Boyd Malcolm Richard
Hodge Richard Anthony Vere
Novartis International Pharmaceutical Ltd.
Savitsky Thomas R.
Travers Russell
LandOfFree
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