Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarbo

Details Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarbo Use of 2,6-diamino-4-substituted-1,4-dihydropyridine-3,5-dicarbo

1974-03-27

1976-05-18

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424251, 424258, 424263, 424274, A61K 31455

Patent

active

039579980

ABSTRACT:
2,6-Diamino-1,4-dihydropyridines bearing carbonyl functions in the 3- and 5-positions and being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2,6-diamino-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an amidine with either an aldehyde or an ylidenecyanoacetoacetic acid ester.

REFERENCES:
patent: 3592895 (1971-07-01), Hepworth et al.
patent: 3631045 (1971-12-01), Kim et al.

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