Use of 2,5-anhydro-D-mannitol as a food intake modifier

Details Use of 2,5-anhydro-D-mannitol as a food intake modifier Use of 2,5-anhydro-D-mannitol as a food intake modifier

1986-09-23

1989-02-28

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

514473, 514910, A61K 31045

Patent

active

048086266

ABSTRACT:
A novel method for altering the food intake of a mammal is disclosed wherein 2,5-anhydro-D-mannitol (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperitoneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the lower limit of sufficiently nor the upper limit of activity have yet to be identified.

REFERENCES:
Kissileff, H. R. et al., "Physiology of the Control of Food Intake", Ann. Rev. Nutri., 2:371-418 (1982).
Russek, M., "Current Status of the Hepatostatic Theory of Food Intake Control", Appetite, 2:137-143 (1981).
Friedman, M. I. et al., "The Physiological Psychology of Hunger: A Physiological Perspective", Physiological Review, 83(6):409-431 (1976).
Riquelme, P. T. et al., "Mechanism of Action of 2,5-Anhydro-D-Mannitol in Hepatocytes", Journal of Biological Chemistry, 259(8):5115-5123 (Apr. 25, 1984).
Stevens, H. C. et al., "2,5-Anhydro Mannitol Inhibits Gluconeogenesis from Dihydroxyacetone in Rat Hepatocytes", Fed. Proc., 42, Part 2, Abstract No. 2384 (1983).
Stevens, H. C. et al., "2,5-Anhydro-D-Mannitol Inhibits Glycogenolysis in Isolated Rat Hepatocytes", Fed. Proc., 40, Part 1, Abstract 3479 (1981).
Hanson, R. L. et al., "Hypoglycemic Effect on 2,5-Andro-D-Mannitol", Fed. Proc., 42 (Part 2), Abstract No. 1453 (1983).
Raushel, F. M. et al., "The Substrate and Anomeric Specificity of the Fructokinase", Journal of Biological Chemistry, 248(23):8174-8177 (Dec. 10, 1973).
Riquelme, P. T. et al., "Inhibition by 2,5-Anhydromannitol of Glycolysis in Isolated Rat Hepatocytes and in Ehrlich Ascites Cells", Proc. Natl. Acad. Sci. U.S.A., 82:78-82 (Jan. 1985).
Riquelme, P. T. et al., "Regulation of Carbohydrate Metabolism by 2,5-Anhydro-D-Mannitol", Proc. Natl. Acad. Sci. U.S.A., 80:4301-4305 (Jul. 1983).
Hanson, R. L. et al., "Inhibition of Gluconeogenesis and Glycogenolysis by 2,5-Anhydro-D-Mannitol", Journal of Biological Chemistry, 259(1):218-223 (Jan. 10, 1984).

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