Use of 2,5-anhydro-d-mannitol as a food intake modifier

Details Use of 2,5-anhydro-d-mannitol as a food intake modifier Use of 2,5-anhydro-d-mannitol as a food intake modifier

1988-08-15

1990-09-04

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

C-o-group doai

A61K 31045

Patent

active

049545310

ABSTRACT:
A novel method for altering the food intake of a mammal is diclosed wherein 2,5-anhydro-D-mannito (2,5-AM) is administered to that mammal in an amount sufficient to alter its food intake. Preferably, normal feeding and fasting periods, and most preferably diurnal feeding and fasting periods, are identified. The mammal receives an intragastric, or intraperitoneal, or intravenous administration within two hours in advance of the onset of the feeding period to decrease food intake, or within two hours of the onset of the fasting period to increase intake. The subject mannitol is preferably administered in amounts of 50-800 mg/kg, although neither the low limit of sufficiency nor the upper limit of activity have yet to be identified.

REFERENCES:
Kissileff, H. R. et al., "Physiology of the Control of Food Intake", Ann. Rev. Nutri., 2:371-418 (1982).
Russek, M., "Current Status of the Hepatostatic Theory of Food Intake Control", Appetite, 2:137-143 (1981).
Friedman, M. I. et al., "The Physiological Psychology of Hunger: A Physiological Perspective", Physiological Review, 83(6):409-431 (1976).
Riquelme, P. T. et al., "Mechanism of Action of 2,5-Anhydro-D-Mannitol in Hepatocytes", Journal of Biological Chemistry, 259(8):5115-5123 (Apr. 25, 1984).
Stevens, H. C. et al., "2,5-Anhydro Mannito Inhibits Gluconeogenesis from Dihydroxyacetone in Rat Hepatocytes", Fed. Proc., 42, Part 2, Abstract No. 2384 (1983).
Stevens, H. C. et al., "2,5-Anhydro-D-Mannitol Inhibits Glycogenolysis in Isolated Rat Hepatocytes", Fed. Proc., 40, Part 1, Abstract 3479 (1981).
Hanson, R. L. et al., "Hypoglycemic Effect on 2,5-Andro-D-Mannitol", Fed. Proc., 42 (Part 2), Abstract No. 1453 (1983).
Raushel, F. M. et al., "The Substrate and Anomeric Specificity of the Fructokinase", Journal of Biological Chemistry, 248(23):8174-8177 (Dec. 10, 1973).
Requelme, P. T. et al., "Inhibition by 2,5-Anhydromannitol of Glycolysis in Isolated Rat Hepatocytes and in Ehrilich Ascites Cells", Proc. Natl. Acad. Sci. USA, 82:78-82 (Jan. 1985).
Riquelme, P. T. et al., "Regulation of Carbohydrate Metabolism by 2,5-Anhydro-D-Mannitol", Proc. Natl. Acad. Sci. USA, 80:4301-4305 (Jul. 1983).
Hanson, R. L. et al., "Inhibition of Gluconneogenesis and Glycogenolysis by 2,5-Anhydro-Mannitol", Journal of Biological Chemistry, 259(1):218-223 (Jan. 10, 1984).

Affiliated with

Also associated with

Rating

Use of 2,5-anhydro-d-mannitol as a food intake modifier does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of 2,5-anhydro-d-mannitol as a food intake modifier, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of 2,5-anhydro-d-mannitol as a food intake modifier will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-442455