Use of 15-lipoxygenase inhibitors for treating obesity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S342000, C514S909000

Reexamination Certificate

active

08048900

ABSTRACT:
The invention concerns the treatment of obesity, in particular abdominal visceral obesity. More specifically, the invention concerns the use of selective 15-lipoxygenase (LO) inhibitors for preparing medicines useful in the treatment of obesity, or at least abdominal visceral obesity, and/or its consequences.

REFERENCES:
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patent: WO 2007/085775 (2007-08-01), None
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Weinstein, et al. (Mar. 1, 2005) “Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase.” Bioorganic & Medicinal Chemistry Letters 15(5): 1435-1440.
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Written Opinion dated Sep. 21, 2009 for International Application No. PCT/FR2007/050711.
Cornicelli JA et al, “15-Lipoxygenase and its inhibition: a novel therapeutic target for vascular disease”, Curr Phram Des. Jan. 1999; 5(1);11-20 (PubMed Abstract).
Cichewicz et al, “Redox Inactivation of Human 15-Lipoxygenase by Marine-Derived Meroditerpenes and Synthetic Chromanes: Archetypes for a Unique Class of Selective and Recyclable Inhibitors”, J. Am. Chem. Soc. 2004, 126, 14910-14920.
Segraves et al, “Probing the Activity Differences of Simple and Complex Brominated Aryl Compounds against 15-soybean, 15-Human, and 12-Human Lipoxygenase”, J. Med. Chem. 2004, 47, 4060-4065.

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