Use of 1.alpha.-hydroxylated-19-nor-vitamin D compounds to treat

Details Use of 1.alpha.-hydroxylated-19-nor-vitamin D compounds to treat Use of 1.alpha.-hydroxylated-19-nor-vitamin D compounds to treat

1992-11-20

1994-06-14

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

9,10-seco- cyclopentanohydrophenanthrene ring system doai

514168, 514169, 514171, 552653, A61K 31595, A61K 3156

Patent

active

053210182

ABSTRACT:
A novel use for 1.alpha.-hydroxylated-19-nor-vitamin D compounds to treat psoriasis inasmuch as these compounds when administered to humans are converted to a metabolite, such as a 1.alpha.,25-dihydroxylated compound, which metabolite in vitro will cause differentiation in a human cell line.

REFERENCES:
patent: 4195027 (1980-03-01), DeLuca et al.
patent: 4237125 (1980-12-01), Bannai et al.
patent: 4610978 (1986-09-01), Dikstein et al.
patent: 4728643 (1988-03-01), Holick et al.

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