Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-01-19
1990-03-13
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31435
Patent
active
049083694
ABSTRACT:
The present invention pertains to the use of 1,4-disubstituted-piperidinyl compounds in the treatment of insomnia.
Said compounds have the following general formula: ##STR1## wherein: each of R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, a C.sub.1-6 alkyl group, halogen, trifluoromethyl, hydroxy, a C.sub.1-6 alkoxy group, or an amino group; n is 2, 3, or 4; and the pharmaceutically acceptable acid addition salts thereof.
REFERENCES:
Chem. Abst. 106-156281K (1987).
5-Hydroxytryptamine-2 antagonist increase human slow wave sleep, Brian Research, 378,(1986) 164-168 Idzikowski, et al.
Does ritanserin, a potent serotonin-S.sub.2 antagonists, store energetic functions during the night? Journal of the Royal Society of Medicine, vol. 80, pp. 409-413, (1987), Janssen.
No Evidence of Sedative Effects From Ritanserin in Healthy Volunteers. Collegium Internationale Neuro-Psychopharmacologicum, San Juan, Puerto Rico/Caribe Hilton International, Dec. 14-17, 1986.
Evidence for serotonin-S.sub.2 receptor involvement in analgesia in humans, from the European Journal of Pharmacology, 130(1986) 311-314, Sandrini, et al.
Safety Evaluation of Ritanserin-An Investigational Serotonin Antagonist, from the Drug Intelligence and Clinical Pharmacy, vol. 20, Oct. 1986, Barone, et al.
Hinze Christian K.
Orwin John M.
Schechter Paul J.
Dixon J. Michael
Friedman Stanley J.
Merrell Dow Pharmaceuticals Inc.
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