Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach comp

Details Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach comp Use of 1-(1-pyrrolidinylcarbonyl)pyridinium salts to attach comp

1990-06-18

1992-10-13

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530403, 530404, 530405, 530408, 530409, 530812, 530815, 530816, 435180, 435181, 436531, 436532, C12Q 168, C07H 2100, C07K 700, C12N 1108

Patent

active

051551667

ABSTRACT:
Useful materials for diagnostic tests, affinity chromatography, enzymatic reactions and immunoassays are prepared by covalently attaching reactive compounds containing reactive amino or sulfhydryl groups to polymeric particles having pendant carboxyl groups on the outer surfaces. Such reactive compounds include biologically reactive species, including enzymes, polypeptides and proteins. This attachment is carried out using specific carbamoylonium compounds, namely certain 1-(1-pyrrolidinylcarbonyl)pyridinium salts. These compounds react with the carboxyl groups on the particles to form intermediate reactive groups which then react with the amino or sulfhydryl groups to form a covalent linkage between particle and reactive compound. A kit comprises polymeric particles having carboxyl groups on the outer surfaces, and a 1-(1-pyrrolidinylcarbonyl)pyridinium salt.

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