Use of 1,1,1,2-Tetrafluoroethane for measuring lung...

Details Use of 1,1,1,2-Tetrafluoroethane for measuring lung... Use of 1,1,1,2-Tetrafluoroethane for measuring lung...

2006-08-14

2010-02-16

Mallari, Patricia C (Department: 3735)

Surgery

Diagnostic testing

Respiratory

C600S529000, C600S538000

Reexamination Certificate

active

07662107

ABSTRACT:
1,1,1,2-Tetrafluoroethane (norflurane) is used as a tracer/trace gas for measuring the lung function because of its simple detectability, physiological harmlessness, environmental friendliness and ready availability. Especially advantageous is the possibility of the optical concentration measurement of 1,1,1,2-tetrafluoroethane for the measurement of the lung function and especially for the determination of the FRC during respiration during anesthesia, without cross sensitivity occurring during the measurement with respect to anesthetics.

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Emmen et al. “Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) following whole-body exposure”. Regul Toxicol Pharmacol. Aug. 2000; 32(1):22-35. Abstract only.
Victor W. Pikes et al.; Disposition of Inhaled 1, 1, 1, 2-Tetrafluoroethane (HFA134A) in Healthy Subjects and in Ptients With Chronic Airflow Limitation; Measurement by 18F-Labeling and Whole-Body gamma-counting; Drug Metabolism and Disposition, Bd. 23, Nr. 8, 1995, Seiten 832-839, XP008104470; pp. 832-839.

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