Use, in a composition, as cyclooxygenase activator and/or stabil

Details Use, in a composition, as cyclooxygenase activator and/or stabil Use, in a composition, as cyclooxygenase activator and/or stabil

1996-04-05

1998-05-26

Witz, Jean C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Oxidoreductases

435188, 435189, 514269, A61K 3844, C12N 996, C12N 902, A01N 4354

Patent

active

057560927

ABSTRACT:
A composition and a method of treating alopecia or dermatological conditions with said composition are disclosed. The composition comprises at least one pyrimidine derivative substituted at the 6th position that activates and/or stabilizes cyclooxygenase, a pharmaceutically or cosmetically acceptable carrier and/or adjuvant and one of the following: a cyclooxygenase enzyme or a cyclooxygenase enzyme and at least one cyclooxygenase substrate comprising a polyunsaturated fatty acid having at least 20 carbon atoms. The composition is applied topically to the affected area or can be administered systemically.

REFERENCES:
patent: 4973474 (1990-11-01), Hocquaux
patent: 5356898 (1994-10-01), Belliotti et al.
J Lab Clin Med , Nov. 1989, 114 (5), pp. 575-578, U.S. O'Barr et al.
Biochem Pharmacol, Mar. 1, 1988, 37 (5), pp. 867-874, England, Kvedar et al.
Cancer Biochem Biophys, Oct. 1994, 14 (3), pp. 211-220, England, Billings et al.
Journal of Investigative Dermatology, 102 (4), 1994, 631, Grossman et al.

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