Use for topsentin compounds and pharmaceutical compositions cont

Details Use for topsentin compounds and pharmaceutical compositions cont Use for topsentin compounds and pharmaceutical compositions cont

1993-02-24

1994-03-01

Friedman, S. J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514497, A61K 3131, A61K 31495

Patent

active

052907775

ABSTRACT:
A novel use for the class of biologically active bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.

REFERENCES:
Faulkner, D. J. (1984) "Marine Natural Products: Metabolites of Marine Invertebrates" Natural Products Reports 1:551-598.
Uemura, Daisuke, Kanuji Takahashi, Tashihiro Yamamoto Chuji Katzyama, Jiro Tanaka, Yasuaki Okumura, and Yoshimasa Hirata (1985) "Norhalichondrin A: An Antitumor Poyether Macrolide from a Marine Sponge" J. Am. Chem. Soc. 107:4796-4898.
Norton, Raymond S., and Robert J. Wells (1982) "A Series of Chiral Polybrominated Biindoles from the Marine Blue-Green Alga Rivularia firma. Application of .sup.13 C NMR Spin-Lattice Relaxation Data and .sup.13 C-.sup.1 H Coupling Constants to Structure Elucidation" J. Am. Chem. Soc. 104(13)3628-3635.
Moquin, Carole, and Michele Guyot (1984) "Grossularine, A Novel Indole Derivative From the Marine Tunicate, Dendrododoa Grossularia" Tetrahedron Letters 25(44):5047-5048.
Faulkner, D. J. (1987) "Marine Natural Products" Natural Products Reports 4(5):539-576.
Faulkner, D. J. (1986) "Marine Natural Products" Natural Products Reports 3:1-33.

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