Use for tachykinin antagonists to treat emesis

Details Use for tachykinin antagonists to treat emesis Use for tachykinin antagonists to treat emesis

1995-12-27

1998-08-25

Criares, Theodore J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514213, 514214, 514221, 514304, 514559, 514561, 514568, 514569, 514872, A61K 3144, A61K 3155, A61K 31205, A61K 3119

Patent

active

057983631

ABSTRACT:
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel tachykinin antagonists of formula (I), processes for their preparation, pharmaceutical compositions containing them and their medical use. ##STR1## wherein R represents the ring A ##STR2## or 2-pyridinyl or 2-pyridinyl-N-oxide; R.sup.1 is selected from halogen atoms and C.sub.1-4 alkyl, C.sub.1-4 alkoxy, trifluoromethyl, and S(O).sub.n C.sub.1-4 alkyl groups;

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