Use for bis-heterocyclic compounds and pharmaceutical compositio

Details Use for bis-heterocyclic compounds and pharmaceutical compositio Use for bis-heterocyclic compounds and pharmaceutical compositio

1994-10-28

1996-03-05

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544373, 544384, 5483121, C07D24102, C07D40302, C07D24104, A61K 31495

Patent

active

054969506

ABSTRACT:
A novel use for the class of biologically active bis-heterocyclic, e.g., bis-indole alkaloid compounds, which have been named topsentins, nortopsentins, hamacanthins, or dragmacidins, pharmaceutical compositions containing them, methods of producing the compounds, and methods of using the compounds are disclosed. Specifically, the novel utility pertains to the anti-inflammatory properties exhibited by the bis-indole compounds and their analogs.

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patent: 4895844 (1990-01-01), Komoto et al.
patent: 4970226 (1990-11-01), Sun et al.
Faulkner, D. J. (1984) "Marine Natural Products: Metabolites of Marine Invertebrates" Natural Products Reports 1:551-598.
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Faulkner, D. J. (1987) "Marine Natural Products" Natural Products Reports 4(5):539-576.
Uemura, D. et al. (1985) "Norhalichondrin A: An Antitumor Polyether Macrolide from a Marine Sponge" J. Am. Chem. Soc. 107:4796-4798.
Moquin, C., M. Guyot (1984) "Grossularine, A Novel Indole Derivative from the Marine Tunicate, Dendrodoa grossularia" Tetrahedron Letters 25(44):5047-5048.
Norton, R. S., R. J. Wells (1982) "A Series of Chiral Polybrominated Biindoles from the Marine Blue-Green Alga Rivularia firma. Application of .sup.13 C NMR Spin-Lattice Relaxation Data and .sup.13 C-.sup.1 H Coupling Constants to Structure Elucidation" J. Am. Soc. 104(13):3628-3635.

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