Surgery – Means for introducing or removing material from body for... – Treating material introduced into or removed from body...
Patent
1994-10-07
1997-09-16
Clarke, Robert A.
Surgery
Means for introducing or removing material from body for...
Treating material introduced into or removed from body...
604307, 424430, 424 7825, 424DIG14, 514843, 514967, A61M 3100, A61F 606, A61K 3179
Patent
active
056674929
ABSTRACT:
The present invention provides a composition and use of a composition comprising a bioadhesive cross-linked polycarboxylic acid polymer formulation that enables the use of relatively low mounts of anti-STD infectants, such as N-9, to be used to prevent infection by STDs without causing the irritation to genital tissue that often accompanies higher doses of anti-STDs. The bioadhesive polymer maintains greater contact between the anti-STD agent and the infectant for a much greater period of time, enabling a lower concentration to act longer on the infectant, when compared to currently-available commercial applications containing N-9. Such delivery will enable a safe and non-irritating decrease in the risk of infection with STDs, including HIV.
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Kreiss, J., et al., Efficacy of Nonoxynol 9 Contraceptive Sponge Use in Preventing Heterosexual Acquisition of HIV, Jul. 22/29, 1992, JAMA, vol. 268(4): 477-82.
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Whaley, K.J., et al., Nonoxynol-9 Protects Mice Against Vaginal Transmission of Genital Herpes Infections, 1993, J.I.D., vol. 1993: 1009-11.
Pearce-Pratt, R., et al., Studies of Adhesion of Lymphocytic Cells: Implications for Sexual Transmission of HIV, 1993, Biology of Reproduction, vol. 48: 431-45.
Bologna William J.
Levine Howard L.
Cho David
Clarke Robert A.
Columbia Laboratories, Inc.
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