Ursodeoxycholic acid derivatives and methods for producing them

Details Ursodeoxycholic acid derivatives and methods for producing them Ursodeoxycholic acid derivatives and methods for producing them

1998-04-30

2000-06-13

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

514 26, C07J 1700

Patent

active

060751320

ABSTRACT:
Disclosed are ursodeoxycholic acid derivatives having an increased solubility in water, and methods for producing the derivatives. To produce the derivatives, ursodeoxycholic acid is protected at its carboxyl group with a benzyl group, then reacted with tetrabenzyl-acetic acid-oxyglucoside of the following formula (1), and de-benzylated; or ursodeoxycholic acid is protected at its hydroxyl group with a t-butyldimethylsilyl group, then reacted with tetrabenzyl-2-hydroxyethyloxyglucoside of the following formula (2), and de-t-butyldimethylsilylated and de-benzylated. ##STR1##

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