Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1994-08-25
1996-07-09
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514937, 514944, 514951, 514974, A61K 3156
Patent
active
055345050
ABSTRACT:
The active agent ursodeoxycholic acid has proved therapeutically active in infants, inter alia for the treatment of cholestatic hepatic diseases. A problem when administering this active agent, a bile acid, to infants is its extreme bitterness. As a result of the present invention a taste-acceptable, liquid administration form for ursodeoxycholic acid with an adequately high active agent concentration is described. The liquid to be ingested is a suspension prepared accompanied by the addition of a swelling and/or thickening agent, which contains the active agent mainly in fine crystalline form as the disperse phase and only in a much smaller proportion dissolved in the aqueous dispersant. A remaining residual bitterness can be additionally masked by the addition of .beta.-cyclodextrin or suitable taste correcting agents.
REFERENCES:
patent: 3639597 (1972-02-01), Hannah
patent: 4242360 (1980-12-01), Pailer et al.
patent: 4264583 (1981-04-01), Jandacek
patent: 5302398 (1994-04-01), Egidio et al.
Dees Jos,e G.
Medichemie AG
Williams Rosalynd A.
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