Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1983-02-03
1985-07-09
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
2601125R, C07C10352, A61K 3702
Patent
active
045281890
ABSTRACT:
UI (Urotensin I) or white sucker urotensin, obtained from Catostomus commersoni, has the formula: H-Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met- Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr -Leu-Asp-Glu-Val-NH.sub.2. Analogs have been synthesized that are at least as potent as UI, and UI or such an analog or a fragment of either or a pharmaceutically acceptable salts of any of the foregoing, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals to achieve a substantial elevation of ACTH, .beta.-endorphin, .beta.-lipotropin and corticosterone levels and/or an increase in intestinal blood flow and/or a lowering of systemic blood pressure and/or a changing of regional blood distribution over an extended period of time. In the analogs, one or more of the first three N-terminal residues is deleted and substituted by a peptide fragment up to 5 amino acids long and/or an acylating agent containing up to 7 carbon atoms is added at the N-terminal.
REFERENCES:
patent: 4385050 (1983-05-01), Lederis et al.
Lederis et al., Endocrine Society Meeting, 64th Annual Meeting, Jun. 16-18, 1982, abst. A756.
Lederis et al., Proceedings of the Western Pharmacological Society, vol. 25, 1982, pp. 223-227.
Lederis et al., Science, 218, No. 4568, 162-164, (Oct. 8, 1982).
Lederis Karl P.
MacCannell Keith L.
Rivier Jean E. F.
Moezie F. T.
Phillips Delbert R.
The Salk Institute for Biological Studies
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