Urotensin peptides

Details Urotensin peptides Urotensin peptides

1987-09-28

1990-03-13

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, A61K 3700, C07K 710

Patent

active

049083520

ABSTRACT:
Maggy UI (Urotensin I) or flathead sole urotensin, obtained from Hippoglossides Elassodon has the formula: H-Ser-Glu-Glu-Pro-Pro-Met-Ser-Ile-Asp-Leu-Thr-Phe-His-Met-Leu-Arg-Asn-Met- Ile-His-Arg-Ala-Lys-Met-Glu-Gly-Glu-Arg-Glu-Gln-Ala-Leu-Ile-Asn-Arg-Asn-Leu -Leu-Asp-Glu-Val-NH.sub.2. Analogs have been synthesized that are at least as potent as Maggy UI, and Maggy UI or such an analog or a biologically active fragment of either or pharmaceutically acceptable salts of any of the foregoing, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals to achieve a substantial elevation of ACTH, .beta.-endorphin, .alpha.-lipotropin and corticosterone levels and/or an increase in intestinal blood flow and/or a lowering of systemic blood pressure and/or a changing of regional blood distributio over an extended period of time. In the analogs, one or more of the first three N-terminal residues is deleted and is optionally substituted by a peptide fragment up to 5 amino acids long, and/or an acylating agent containing up to 7 carbon atoms is optionally added at the N-terminus.

REFERENCES:
patent: 4385050 (1983-05-01), Lederis et al.
patent: 4528189 (1985-07-01), Lederis et al.
patent: 4533654 (1985-08-01), Lederis et al.

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