Urotensin II receptor antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S253040, C514S253060, C514S253090, C514S254020, C514S254040, C514S254050, C514S254080, C514S323000, C514S417000, C544S238000, C544S295000, C544S363000, C544S364000, C544S366000, C544S367000, C544S370000, C544S373000, C546S200000, C546S277100, C548S455000, C548S466000, C548S472000

Reexamination Certificate

active

08008299

ABSTRACT:
This invention is directed to a compound of Formula (I):and forms thereof, wherein A, B, E, G, X and L2are as defined herein and their use as urotensin II receptor antagonists.

REFERENCES:
patent: 6583144 (2003-06-01), Ohkura et al.
patent: 6884887 (2005-04-01), Riermeier et al.
patent: 6911464 (2005-06-01), Man et al.
patent: 7043052 (2006-05-01), Rhoads
patent: 2004/0259873 (2004-12-01), Man et al.
patent: 2004/0267051 (2004-12-01), Boerner et al.
patent: 2005/0203090 (2005-09-01), Man et al.
patent: 2007/0027163 (2007-02-01), Bissantz et al.
patent: WO 98/52919 (1998-11-01), None
patent: WO 01/05741 (2001-01-01), None
patent: WO 01/05741 (2001-01-01), None
patent: WO 03/014061 (2003-02-01), None
patent: WO 2004/078114 (2004-09-01), None
patent: WO 2004/080422 (2004-09-01), None
patent: WO 2004/080422 (2004-09-01), None
patent: WO 2004/080423 (2004-09-01), None
patent: WO 2004/080423 (2004-09-01), None
patent: WO 2005/034873 (2005-04-01), None
patent: WO 2005/034873 (2005-04-01), None
patent: WO2007/081995 (2007-07-01), None
patent: WO 2008/153902 (2008-12-01), None
Vippagunta et al. Advanced Drug Delivery Reviews, vol. 48, pp. 3-26 (2001).
European Search Report, Application No. 08768153.2-1219/2161994; PCT/US2008007076.
International Search Report, PCT/US08/07076, Jun. 5, 2008.
Pearson et al, “Urotensin II: A somatostatin-like peptide in the caudal neurosecretory system of fishes,” Proc. Natl. Acad. Sci. USA, 1980, pp. 5021-5024, vol. 77, No. 8.
Ames, et al, “Human-urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14,” Nature, 1999, pp. 282-286, vol. 401, London.
Tal, et al, “A Novel Putative Neuropeptide Receptor Expressed in Neural Tissue, Including Sensory Epithelia,” Biochem. Biophys. Res. Commun., 1995, pp. 752-759, vol. 209.
Marchese, et al, “Cloning and Chromosomal Mapping of Three Novel Genes, GPR9, GPR10, and GPR14, Encoding Receptors Related to Interleukin 8, Neuropeptide Y, and Somatostatin Receptors,” Genomics, 1995, pp. 335-344; vol. 29.
Conlon, et al, “Distribution and Molecular Forms of Urotensin II and its role in Cardiovascular Regulation in Vertebrates,” J. Exp. Zool., 1996, pp. 226-238, vol. 275.
Bohn, et al, “Urotensin II evokes potent vasoconstriction in humans in vivo,” Br. J. Pharmacol., 2002, pp. 25-27, vol. 135.
Douglas, et al, “Human Urotensin-II, the Most Potent Mammalian Vasoconstrictor Identified to Date, as a Therapeutic Target for the Management of Cardiovascular Disease,” Trends Cardiovasc. Med., 2000, pp. 229-237, vol. 10.
Zou, et al, “Urotensin II induces hypertrophic responses in cultured cardiomyocytes from neonatal rats,” FEBS Letters, 2001, pp. 57-60, vol. 508.
Watanabe, et al, “Synergistic Effect of Urotensin II With Mildly Oxidized LDL on DNA Synthesis in Vascular Smooth Muscle Cells,” Circulation, 2001, pp. 16-18, vol. 104.
Lim, et al, “Differential Effect of Urotensin II on Vascular Tone in Normal Subjects and Patients With Chronic Heart Failure,” Circulation, 2004, pp. 1212-1214, vol. 109.
Bousette, et al, “Increased expression of urotensin II and its cognate receptor GPR 14 in atherosclerotic lesions of the human aorta,” Antherosclerosis, 2004, pp. 117-123, vol. 176.
Totsune, et al, “Role of urotensin II in patients on dialysis,” Lancet, 2001, pp. 810-811, vol. 358.
Totsune, et al, “Increased plasma urotensin II levels in patients with diabetes mellitus,” Clin. Sci., 2003, pp. 1-5, vol. 104.
Gartlon, et al, “Central effects of urotensin-II following ICV administration in rats,” Psychopharmacology, 2001, pp. 426-433, vol. 155.
Gartlon, et al, “Urotensin-II, a neuropeptide ligand for GPR 14, induces c-fosin the rat brain,” Eur. J. of Pharmacol., 2004, pp. 95-98, vol. 493.
Matsumoto, et al, “Intracerebroventricular administration of urotensin II promotes anxiogenic-like behaviors in rodents,” Neuroscience Letters, 2004, pp. 99-102, vol. 358.
Kinney, et al, “Structure-Function Analysis of Urotensin II and its Use in the Construction of a Ligand-Receptor Working Model”, Angew. Chem. Int. Ed., 2002, pp. 2940-2944, vol. 41, No. 16.
Silvestre, et al, “Inhibition of Insulin Release by Urotensin II—A Study on the Perfused Rat Pancreas,” Horm. Metab. Res., 2001, pp. 379-381, vol. 33.
Gillaspy, et al, “A Simple Method for the Formation of Cycolpropylamines: The First Synthesis of Tricyclopropylamine,” Tetrahedron Letters, 1995, pp. 7399-7402, vol. 36.
Qi et al, “Characterization of functional urotensin II receptors in human skeletal muscle myoblasts: comparison with angiotensin II receptors,” Peptides, 2005, pp. 683-690, No. 26, Elsevier.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Urotensin II receptor antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Urotensin II receptor antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urotensin II receptor antagonists will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2703867

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.