Uropathogenic E. coli D-serine detoxification operon

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S004000, C435S029000, C435S243000

Reexamination Certificate

active

11289989

ABSTRACT:
Disclosed are methods of detecting uropathogenicE. coligenes that are differentially expressed in response to D-serine. Also disclosed are methods of characterizing bacterial isolates from clinical samples based on the ability to metabolize D-serine.

REFERENCES:
patent: 3873269 (1975-03-01), Kraffczyk et al.
patent: 4803170 (1989-02-01), Stanton et al.
patent: 6162827 (2000-12-01), Javitt
patent: 6617488 (2003-09-01), Springer et al.
Aiyar, S.E., et al., “Upstream A-tracts increase bacterial promoter activity through interactions with the RNA polymerase alpha submit,” PNAS (1998) 95(25):14652-14657.
Arthur, M., et al., “Restriction fragment length polymorphisms among uropathogenicEscherichia coliisolates: pap-related sequences compared with rrn operons,” Inf. Immun. (1990) 58:471-479.
Arthur, M., et al., “Structure and copy number of gene clusters related to the pap P-adhesin operon o furopathogenicEscherichia coli,” Inf. Immun. (1989) 57(2):314-321.
Arthur, M., et al., Molecular epidemiology of adhesin and hemolysin virulence factors among uropathogenicEscherichia coli, Infect. Immun. (1989) 57:303-313.
Bloom, F.R. et al., “Isolation and characterization of D-serine deaminase constitutive mutants by utilization of D-serine as sole carbon or nitrogen source,” J. Bacteriol. (1975) 121:1078-1084.
Bloom, F.R. et al., “Positive control in the D-serine deaminase system ofEscherichia coliK-12,” J. Bacteriol. (1975) 121(3):1092-1101.
Bruckner, J. et al., “Quantification of D-amino acids in human urine using GC-MS and HPLC,” Amino Acids (1994) 6: 205-211.
Connell, H. et al., “Type 1 fimbrial expression enhancesEscherichia colivirulence for the urinary tract,” PNAS (1996) 93:9827-9832.
Datsenko, K. et al., “One-step inactivation of chromosomal genes inEscherichia coliK-12 using PCR products,” PNAS (2000) 97(12):6640-6645.
Guzman, L. et al., “Tight regulation, modulation and high-level expression by vectors containing the arabinose P BAD promoter,” J. Bacteriol. (1995) 177(14):4121-4130.
Heincz, M.C. et al., “Purification and characterization of D-serine deaminase activator protein,” J. Bacteriol. (1984) 160:42-49.
Huang, Y. et al., “Urinary excretion of D-serine in human: comparison of different ages and species,” Biol. Pharm. Bull. (1998) 21(2):156-162.
Johnson, J. et al., “P Fimbriae and other virulence factors inEscherichia coliurosepsis: association with patients' characteristics,” Infect. Dis. (1987) 156:225-229.
Johnson, J. et al., “O, K, and H antigens predict virulence factors, carboxylesterase B pattern, antimicrobial resistance, and host compromise amongEscherichia colistrains causing urosepsis,” J. Infect. Dis. (1994) 169:119-126.
Johnson, J.R. et al., “Aerobactin and other virulence factor genes among strains ofEscherichia colicausing urosepsis: association with patient characteristics,” Infect. Immun. (1988) 56:405-412.
Kinder, S.A. et al., “Cloning of the YenI restriction endonuclease and methyltransferase fromYersinia enterocoliticaserotype O8.and construction of a transformable R-M+ mutant,” Gene (1993) 136:271-275.
Long, A.D. et al., “Improved statistical inference from DNA microarray data using analysis of variance and a bayesian statistical framework,” J. Biol. Chem. (2001) 276(23):19937-19944.
McFall, E. et al., “Thermosensitive regualtion of D-serine deaminase synthesis in a mutant ofEscherichia coliK-12,” Molec. Gen. Genetics (1970) 106(4):371-377.
McFall, E., “Dominance studies with stable merodiploids in the D-serine deaminase system ofEscherichia coliK-12,” J. Bacteriol. (1967) 94:1982-1988.
McFall, E., “Escherichia coliK-12 mutant forming a temperature-sensitive D-serine deaminase,” J. Bacteriol. (1975) 121(3):1074-1077.
McFall, E., “Pleiotropic mutations in the D-serine deaminase system ofEscherichia coli,” J. Mol. Biol. (1964) 9:754-762.
McFall, E., “Role of adenosine 3′,5′-cyclic monophosphate and its specific binding protein in the regulation of D-serine deaminase synthesis,” J. Bacteriol. (1973) 113(2):781-785.
Mobley, H.L.T. et al., “PyelonephritogenicEscherichia coliand killing of cultured human renal proximal tubular epithelial cells: role of hemolysin in some strains,” Inf. Immun. (1990) 58:1281-1289.
Mothet, J.P. et al., “D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor,” PNAS (2000) 97:4926-4931.
Mulvey, M.A. et al., “Establishment of a persistentEscherichia colireservoir during the acute phase of a bladder infection,” Inf. Immun. (2001) 69(7):4572-4579.
Mulvey, M.A. et al., “Induction and evasion of host defenses by type 1-piliated uropathogenicEscherichia coli,” Science (1998) 282:1494-1497.
Neidhardt, F.C. et al., Culture medium for enterobacteria, J. Bacteriol. (1974) 119:736-747.
Nelson, K.M. et al., “Identification of a locus involved in systemic dissemination ofYersinia enterocolitica,” Inf. Immun. (2001) 69:6201-6208.
Roesch, P.L. et al., “Chirality sensing: D-serine may be a novel environmental cue used by uropathogenicEscherichia coli,” ASM 101stGeneral Meeting, Orlando, Florida (2001) Session No. 214/B Abstract B-279.
Sarkar et al., “Screen-printed amperometric biosensors for the rapid measurement of L- and D-amino acids,” Analyst (1999) 124:865-870.
Silbernagl et al., “D-serine is reabsorbed in rat renal pars recta,” Am. J. Physiol. (1999) 276:F857-863.
Simon, R. et al., “A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in gram negative bacteria,” Biotechnology (1983) 1:784-791.
Sokurenko, E.V. et al., “Pathogenic adaptation ofEscherichia coliby natural variation of the FimH adhesin,” PNAS (1998) 95:8922-8926.
Torres, A.G. et al., “TonB-dependent systems of uropathogenicEscherichia coli: aerobactin and heme transport and tonB are required for virulence in the mouse,” Inf. Immun. (2001) 69:6179-6185.
Tsai et al., “D-serine added to clozapine for the treatment of Schizophrenia,” Am. J. Psychiatry (1999) 156(11):1822-1825.
Valdivia, R.H. et al., “Fluorescence-based isolation of bacterial genes expressed within host cells,” Science (1997) 277:2007-2011.
Wei, Y. et al., “High-density microarray-mediated gene expression profiling ofEscherichia coli,” J. Bacteriol. (2001) 183(2):545-556.
Weyand, N.J. et al., “The essential role of the promoter-proximal subunit of CAP in pap phase variation: Lrp- and helical phase-dependent activation of papBA transcription by CAP from -215,” Mol. Micro. (2001) 39(6):1504-1522.
Whittam, T.S. et al., “Clonal relationships amongEscherichia colistrains that cause hemorrhagic colitis and infantile diarrhea,” Inf. Immun. (1993) 61:1619-1629.
Wolosker, H. et al., “Purification of serine racemase: biosynthesis of the neuromodulator D-serine,” PNAS (1999) 96:721-725.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Uropathogenic E. coli D-serine detoxification operon does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Uropathogenic E. coli D-serine detoxification operon, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Uropathogenic E. coli D-serine detoxification operon will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3934686

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.