Surgery – Controlled release therapeutic device or system
Patent
1996-06-26
1999-01-12
Mendez, Manuel
Surgery
Controlled release therapeutic device or system
6048921, A61K 922
Patent
active
058580174
ABSTRACT:
A method and solution for perioperatively inhibiting a variety of pain, inflammation and smooth muscle spasm processes resulting from urologic procedures. The solution preferably includes multiple pain and inflammation inhibitory agents and spasm inhibitory agents at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is introduced luminally to continuously irrigate a urologic structure during a urologic procedure for preemptive inhibition of pain and inflammation and smooth muscle spasm while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain, inflammation, and spasm includes a serotonin.sub.2 antagonist, a histamine.sub.1 antagonist, a cyclooxygenase inhibitor, a neurokinin.sub.2 antagonist, a purine.sub.2X antagonist, an ATP-sensitive K.sup.+ channel antagonist, a Ca.sup.2+ channel antagonist, one or more nitric oxide donors, a bradykinin.sub.1 antagonist and a bradykinin.sub.2 antagonist.
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Demopulos Gregory A.
Herz Jeffrey M.
Pierce Pamela A.
Mendez Manuel
Omeros Medical Systems, Inc.
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