Urokinase plasminogen activator fragments

Details Urokinase plasminogen activator fragments Urokinase plasminogen activator fragments

1993-10-25

2000-09-19

Kemmerer, Elizabeth

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435215, 4351723, 514 12, 514 13, 514 14, 514 15, 514 16, 514 17, A61K 3849, C12N 972

Patent

active

061207659

ABSTRACT:
Purified uPA peptides having, mitogenic activity and containing as few as six amino acids of the EGF-like domain of uPA.

REFERENCES:
patent: 4940666 (1990-07-01), Boyce et al.
patent: 4999194 (1991-03-01), Broeze et al.
patent: 5366862 (1994-11-01), Venton et al.
Appella et al., "The Receptor-binding Sequence of Urokinase", The Journal of Biological Chemistry, vol. 262, No. 10, pp. 4437-4440, Apr. 5, 1987.
Del Rosso et al., "Modulation of Surface-Associated Urokinase: Binding, Interiorization, Delivery to Lysosomes, and Degradation in Human Keratinocytes", Experimental Cell Research, vol. 193, pp. 346-355, 1991.
Fibbi et al., "Interaction of Urokinase A Chain with the Receptor of Human Keratinocytes Stimulates Release of Urokinase-like Plasminogen Activator", Experimental Cell Research, vol. 187, pp. 33-38, 1990.
Fraki et al., "Uninvolved Skin from Psoriatic Patients Develops Signs of Involved Psoriatic Skin After Being Grafted onto Nude Mice", Science, vol. 215, pp. 685-687, Feb. 5, 1982.
Grant et al., "Active and Pro-plasminogen Activator on the Surface of Human Bladder Cancer Cells Derived from a High Grade Invasive Tumor", Biochemical and Biophysical Research Communications, vol. 172, No. 2, pp. 870-876, Oct. 30, 1990.
Gr.o slashed.ndahl-Hansen et al., "Urokinase-and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo", Invest. Dermatol., vol. 90, No. 6, pp. 790-795, Jun. 1988.
Hibino et al., "Enhanced Expression of Human Pro-urokinase cDNA in Escherichia coli", Agric. Biol. Chem., vol. 52, No. 2, pp. 329-336, 1988.
Kirchheimer et al., "Proliferation of a human epidermal tumor cell line stimulated by urokinase", FASEB J., vol. 1, No. 2, pp. 125-128, 1987.
Lazarus et al., "Proteinase Metabolism in Human Skin: The Role of Plasminogene Activator and Mast Cell Proteinases in Cutaneous Biology", Physiology, Biochemistry, and Molecular Biology of the Skin, 2.sup.ed, Editor Goldsmith, 1991.
Meissauer et al., "Urokinase-Type and Tissue-Type Plasminogen Activators are Essential for in Vitro Invasion of Human Melanoma Cells", Experimental Cell Research, vol. 192, pp. 453-459, 1991.
Miganatti et al., "Tumor Invasion through the Human Amniotic Membrane Requirement for a Proteinase cascade", Cell, vol. 47, pp. 487-498, Nov. 21, 1986.
Nielsen et al., "A 55,000-60,000 M.sub.r Receptor Protein for Urokinase-type Plasminogen Activator", The Journal of Biological Chemistry, vol. 263, No. 5, pp. 2358-2363, Feb. 15, 1988.
Nykjaer et al., "Urokinase receptors in human monocytes", Biochimica et Biophysica Acta, vol. 1050, pp. 399-407, 1990.
Rabbani et al., "An Amino-Terminal Fragment of Urokinase Isolated from a Prostate Cancer Cell Line (PC-3) is Mitogenic for Osteoblast-like Cells", Biochemical and Biophysical Research Communications, vol. 173, No. 3, pp. 1058-1064, Dec. 31, 1990.
Riccio et al., "The human urokinase-plasminogen activator gene and its promoter", Nucleic Acids Research, vol. 13, No. 8, pp. 20-30, 1985.
Roldan et al., "Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis", The EMBO Journal, vol. 9, No. 2, pp. 467-474, 1990.
Tsubol et al., "Bimodal Relationship Between Invasion of the Amniotic Membrane and Plasminogen Activator Activity", Int. J. Cancer, vol. 46, pp. 56-60, 1990.
Fry et al., "Observations on Mitosis in Psoriatic Epidermis", British Journal Dermatology, vol. 82, pp. 19-22, 1970.
Hibino et al., "Urokinase-Plasmonogen Activator (u-PA) is Associated with Keratinocyte Proliferation", XVII MGH Research Symposium and Poster Session, Abstracts of Posters and Oral Presentations, Abst No. 158, Jan. 20, 1993.
Wun et al., "A Proenzyme Form of Human Urokinase", Journal Biological Chemistry, vol. 257, No. 12, pp. 7262-7268, 1982.
Hibino et al., "EGF-like domain of urokinase plasmogen-activator (uPA) stimulates keratinocyte growth", The American Society for Cell Biology, Abstract presented at the Molecular Biology of the Cell 4(Suppl.) 1993. 2/A.
Del Rosso, et al., "Role of specific membrane receptors in urokinase dependent migration of human keratinocytes", The Journal of Investigative Dermatology, vol. 94, No. 3, pp. 310-316, Mar. 1990.
Hibino et al., "EGF-like domain of urokinase plasmogen activator UPA plays an essential role in keratinocyte growth stimulation" Journal of Investigative Dermatology, 100(4):500 (1993).
Rabbani, S.A. et al. J. Biol. Chem. 267:14151-14156 (1992).
Au et al. Nucleotide and deduced amino acid sequences of baboon urokinase-type plasminogen activator. Nucleic Acids Res. (1990) 18:3411.
Sambrook et al. Molecular Cloning: A Laboratory Manual Second Edition vols. 1, 2 and 3. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, New York, U.S.A. Nov., 1989.
Mather et al. The major fat-globule membrane proteins, bovine components 15/16 and guinea-pig GP 55, are homologous to MGF-E8 a murine glycoprotein containing epidermal growth factor-like and factor V/VIII-like sequences. Biochem. Mol. Biol. Int., (199, Mar. 1993.

Affiliated with

Also associated with

Rating

Urokinase plasminogen activator fragments does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Urokinase plasminogen activator fragments, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urokinase plasminogen activator fragments will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1069408