Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2009-12-07
2011-10-25
Chernyshev, Olga N (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S021300, C530S300000, C530S306000, C530S324000
Reexamination Certificate
active
08044025
ABSTRACT:
A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituitary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn IL Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.
REFERENCES:
patent: 6670140 (2003-12-01), Isfort et al.
patent: 6838274 (2005-01-01), Vale, Jr. et al.
patent: 7223846 (2007-05-01), Vale, Jr. et al.
patent: 7638607 (2009-12-01), Vale, Jr. et al.
patent: 2002/0082409 (2002-06-01), Hsu et al.
patent: WO 97/00063 (1997-01-01), None
patent: WO 02/34934 (2002-05-01), None
Hsu and Hsueh, “Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor,”Nature Medicine 7:605-611, 2001.
Hsu et al., “Stresscopins and Their Uses,” U.S. Appl. No. 60/244,128, filed Oct. 26, 2000.
Hsu et al., “Stresscopins and Their Uses,” U.S. Appl. No. 60/276,615, filed Mar. 15, 2001.
Bale et al., “Mice deficient for corticotrophin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress,”nature genetics 24:410-414, 2000.
Bittencourt et al., “Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System,”The Journal of Neuroscience 20(3):1142-1156, 2000.
Bradbury et al., “Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice,”Endocrinology 141(8):2715-2724, 2000.
Chalmers et al., “Localization of Novel Corticotropin-Releasing Factor Receptor (CRF2) mRNA Expression to Specific Subcortical Nuclei in Rat Brain: Comparison with CRF1Receptor mRNA Expression,”The Journal of Neuroscience 15(10):6340-6350, 1995.
Chen et al., “Expression cloning of a human corticotrophin-releasing-factor receptor,”Proc. Natl. Acad. Sci. USA 90:8967-8971, 1993.
Contarino et al., “Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice,”Endocrinology 141(7):2698-2702, 2000.
Coste et al., “Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2,”nature genetics 24:403-409, 2000.
Eddy, Sean R., “Hidden Markov models,”Current Opinion in Structural Biology 6:361-365, 1996.
Elmquist et al., “Unraveling the central nervous system pathways underlying responses to leptin,”nature neuroscience 1(6):445-450, 1998.
Gray et al., “Identification of a Binding Site on the Type II Activin Receptor for Activin and Inhibin,”The Journal of Biological Chemistry 275(5):3206-3212, 2000.
Kishimoto et al., “Deletion ofCrhr2reveals an anxiolytic role for corticotrophin-releasing hormone receptor-2,”nature genetics 24:415-419, 2000.
Lewis, K. et al., “Identificiation of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor,”Proc. Natl. Acad. Sci. USA 98(13): 7570-7575, 2001.
Lovenberg et al., “CRF2α, and CRF2βreceptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues.”Endocrinology 136(9):4139-4142, 1995.
Miranda et al., “Conformationally Restricted Competitive Antagonists of Human/Rat Corticotropin-Releasing Factor,”J Med. Chem. 37:1450-1459, 1994.
Perrin et al., “Identification of a second corticotrophin-releasing factor receptor gene and characterization of a cDNA expressed in heart,”Proc. Natl. Acad. Sci. USA 92:2969-2973, 1995.
Potter et al., “Distribution of corticotrophin-releasing factor receptor mRNA expression in the rat brain and pituitary,”Proc. Natl. Acad. Sci. USA 91:8777-8781, 1994.
Reyes, T.M. et al., “Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors,”Proc. Natl. Acad. Sci. USA 98(5): 2843-2848, 2001.
Rohde et al., “Corticotropin-Releasing Hormone (CRH) Receptors in the Mesenteric Small Arteries of Rats Resemble the (2)-Subtype,”Biochemical Pharmacology 52:829-833, 1996.
Smith et al., “Corticotropin Releasing Factor Receptor 1-Deficient Mice Display Decreased Anxiety, Impaired Stress Response, and Aberrant Neuroendocrine Development,”Neuron20:1093-1102, 1998.
GenBank Database, Accession No. AC005903, Jan. 9, 2003.
GenBank Database, Accession No. AF331517, Mar. 6, 2001.
GenBank Database, Accession No. BE622276, Oct. 20, 2000.
Parkes et al., “Cardiac inotropic actions of urocortin in conscious sheep,”Am. J. Physiol. 272(5 pt. 2):H2115-H2122, 1997.
GenBank Database, Accession No. L23982, Jan. 5, 1995.
GenBank Database, Accession No. BE390203, Jul. 21, 2000.
Sambrook et al.,Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, New York, 2001, Chapter 10, “Melting Temperatures,” p. 10.47.
Vaughan et al., “Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotrophin-releasing factor,”Nature378:287-292, 1995.
Hogenesch John B.
Lewis Kathy A.
Perrin Marilyn H.
Reyes Teresa M.
Rivier Jean E.
Chernyshev Olga N
Research Development Foundation
Seed IP Law Group PLLC
LandOfFree
Urocortin proteins and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Urocortin proteins and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urocortin proteins and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4282835