Urocortin proteins and uses thereof

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S069100, C435S254110, C435S325000, C435S320100, C435S252330, C536S023100, C536S023500, C536S024100

Reexamination Certificate

active

06838274

ABSTRACT:
A human urocortin-related peptide with significant sequence homology to the CRF neuropeptide family was identified. A mouse cDNA was isolated from whole brain poly (A+) RNA that encodes a predicted 38 amino acid peptide protein designated herein as urocortin II. Both human URP and mouse Ucn II are structurally related to the other known mammalian family members, CRF and urocortin (Ucn). These peptides are involved in the regulation of the hypothalamic-pituituary-adrenal axis under basal and stress conditions, suggesting a similar role for URP and Ucn II. Synthesized Ucn-II and URP peptide binds with higher affinity to CRF-R2 than to CRF-R1 Ucn II and human URP appear to be involved in the regulation of body temperature and appetite and may play a role in other stress related phenomenon. These findings identify Ucn II and human URP as a new members of the CRF family of neuropeptides, which are expressed centrally and bind to CRF-R2.

REFERENCES:
patent: 20020082409 (2002-06-01), Hsu
patent: 20030165807 (2003-09-01), Isfort et al.
patent: WO 9700063 (1997-01-01), None
patent: WO 0234934 (2002-05-01), None
Hsu and Hsueh, “Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor,”Nature Medicine7: 605-611, May 2001.
Lewis, K. et al., “Identificiation of urocortin III, and additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor,”Proc. Natl. Acad. Sci. USA 98(13):7570-7575, Jun. 19, 2001.
Reyes, T.M. et al., “Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors,”Proc. Natl. Acad. Sci. USA 98(5): 2843-2848, Feb. 27, 2001.
GenBank Database, Accession No. AC005903, Jan. 9, 2003.
GenBank Database, Accession No. AF331517, Mar. 6, 2001.
GenBank Database, Accession No. BE622276, Oct. 20, 2000.
Hsu, S.Y. et al., “Stresscopins and Their Uses,” U. S. Provisional patent application No. 60/244,128, filed Oct. 26, 2000.
Hsu, S.Y. et al., “Stresscopins and Their Uses,” U.S. Provisional patent application No. 60/276,615, filed Mar. 15, 2001.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Urocortin proteins and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Urocortin proteins and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urocortin proteins and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3403536

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.