Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2005-05-03
2005-05-03
Leary, Louise N. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S007100, C435S975000
Reexamination Certificate
active
06887659
ABSTRACT:
A method for assaying bone resorption rates which consists of quantitating the concentration of peptide fragments derived from bone collagen, found in a body fluid is disclosed. The method includes immunometric assay, fluorometric assay and electrochemical titration. The structure of specific peptide fragments having 3-hydroxypyridinium cross-links found in urine of Paget's disease patients and procedures for making monoclonal antibodies is described.
REFERENCES:
patent: 3600132 (1971-08-01), Goverde
patent: 4094646 (1978-06-01), Stern et al.
patent: 4312853 (1982-01-01), Timpl
patent: 4371374 (1983-02-01), Cerami et al.
patent: 4504587 (1985-03-01), Timpl et al.
patent: 4628027 (1986-12-01), Gay
patent: 4731326 (1988-03-01), Thompson et al.
patent: 4774227 (1988-09-01), Piez et al.
patent: 4973666 (1990-11-01), Eyre
patent: 5140103 (1992-08-01), Eyre
patent: 5300434 (1994-04-01), Eyre
patent: 5607862 (1997-03-01), Eyre
patent: 5945274 (1999-08-01), Eyre
patent: 5962236 (1999-10-01), Eyre
patent: 6025144 (2000-02-01), Eyre
patent: 1287801 (1987-02-01), None
patent: 128 041 (1983-06-01), None
patent: WO 8808980 (1988-11-01), None
Niemela, “Radioimmunoassays for Type III Procollagen Amino-Terminal Peptides in Humans,”Clinical Chemistry, 31:1301-1304 (1985).
Sangiorgi, et al., “Isolation and partial characterization of the entire human proα1 (II) collagen gene,”Nucleic Acids Research, 13:2207-2225 (1985).
Loidl, et al., “Molecular cloning and carboxyl-propeptide analysis of human type III procollagen,”Nucleic Acids Research, 12:9383-9394 (1984).
Wu and Eyre, “Identification of Hydroxypyridinium Cross-Linking Sites in Type II Collagen of Bovine Articular Cartilage,”Biochemistry, 23:1850-1857 (1984).
Pierard, et al., “Radioimmunoassay for the Amino-Terminal Sequences of Type II Procollagen in Human Body Fluids Measuring Fragmented Precursor Sequences,”Analytical Biochemistry, 141:127-136 (1984).
Rohde, et al., “Radioimmunoassay for type III procollagen peptide and its application to human liver disease,”European Journal of Clinical Investigation, 9:451-459 (1979).
Russell, R.G.G., et al., “Biochemical Markers of Bone Turnover in Paget's Disease,”Metab. Bone Dis.&Rel. Res., 4 & 5:255-262 (1981).
Drinkwater, B.L., et al., “Bone Mineral Density After Resumption of Menses in Amenorrheic Athletes,”JAMA, 256:380-382 (1986).
Drinkwater, B.L., et al., “Bone Mineral Content of Amenorrheic and Eumenorrheic Athletes,” theNew England Journal of Medicine, 311:5;277-281 (1984).
Fujimoto, D., “Evidence for Natural Existence of Pyridinoline Crosslink in Collagen,”Biochemical and Biophysical Research Communications, 93:948-953 (1980).
Yamauchi, M. et al., “A Comparative Study of the Distribution of the Stable Crosslink, Pyridinoline, in Bone Collagens from Normal, Osteoblastoma, and Vitamin D-Deficient Chicks,”Biochemical and Biophysical Research Communications, 102:59-65 (1981).
Kuboki, Y., et al., “Location of the Intermolecular Crosslinks in Bovine Dentin Collagen, Solubilization with Trypsin and Isolation of Cross-Link Peptides Containing Dihydroxylysinonorleucine and Pyridinoline,”Biochemical and Biophysical Research Communications, 102:119-126 (1981).
Gunja-Smith, Z. and Boucek, R.J., “Collagen cross-linking compounds in human urine,”Biochemical Journal, 197:759-762 (1981).
Tsuchikura, O., et al., “Pyridinoline Fluorescence in Cyanogen Bromide Peptides of Collagen,”Biochemical and Biophysical Research Communications, 102:1203-1208 (1981).
Tsuda, M., et al., “Pyridinoline is a Real Moiety of Collagen,”Biochemical and Biophysical Research Communications, 104:1407-1412 (1982).
Robins, S.P., “An enzyme-linked immunoassay for the collagen cross-link pyridinoline,”Biochemical Journal, 207:617-620 (1982).
Banes, A.J., et al., “Nonmineralized and Mineralized Compartments of Bone: the Role of Pyridinoline in Nonmineralized Collagen,”Biochemical and Biophysical Research Communications, 113:975-981 (1983).
Fujimoto, D., et al., “Analysis of Pyridinoline, a Cross-Linking Compound of Collagen Fibers, in Human Urine,”J. Biochem., 94:1133-1136 (1983).
Eyre, D.R., et al., “Cross-Linking in Collagen and Elastin,”Ann. Rev. Biochem., 53:717-748 (1984).
Light, N. and Bailey, A.J., “Collagen crosslinks: Location of pyridinoline in type I collagen,”FEBS2409, 182:503-508 (1985).
Fujimoto, D., et al., “Pyridinoline, A Non-Reducible Crosslink of Collagen. Quantitative Determination, Distribution, and Isolation of a Crosslinked Peptide,”Chemical Abstracts89(11):148, (Sep. 11, 1978).
Fujimoto, D., et al., “Analysis of Pyridinoline, A Cross-Linking Compound of Collagen Fibers, in Human Urine,”Chemical Abstracts99(19):446-447, (Nov. 7, 1983).
Eyre, D.R. et al., “Quantitation of Hydroxypyridinium Crosslinks in Collagen by High-Performance Liquid Chromatography,”Analytical Biochemistry, 137:380-388 (1984).
Robins, S.R., et al., “Measurement of the cross linking compound, pyridinoline, in urine as an index of collagen degradation in joint disease,”Annals of the Rheumatic Diseases, 45:969-973 (1986).
Bernard, M.P., et al., “Nucleotide Sequences of Complementary Deoxyribonucleic Acids for the Proα1 Chain of Human Type I Procollagen. Statistical Evaluation of Structures that are Conserved During Evolution,”Biochemistry, 22:5213-5223 (1983).
Goldstein, D., et al., “Simultaneous Measurement of DOPA, DOPAC, and Catecholamines in Plasma by Liquid Chromatography with Electrochemical Detection,”ESA Review, vol. II, No. 1, pp. 2-11 (1986).
Chu, M-L., et al., “Human proα1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons,”Nature310(26):337-340 (1984).
Robins, S.P., et al., “Measurement of Hydroxypyridinium Crosslinks of Collagen as an Index of Bone Matrix Degradation,”An Abstract of a Paper, Lake Garda, Italy (1987).
Kang, A.H. and Gross, J., “Amino Acid Sequence of Cyanogen Bromide Peptides from the Amino-Terminal Region of Chick Skin Collagen,”Biochemistry9:796-804 (1970).
Highberger, J.H., et al., “The Amino Acid Sequence of Chick Skin Collagen α1-CB7,”Biochemistry14(13):2872-2881 (1975).
Fietzek, P.P. and Kuhn, K., “The Covalent Structure of Collagen: Amino Acid Sequence of the N-Terminal Region of α2-CB5 from Rat Skin Collagen,”FEBS Letters36(3):289-291 (1973).
Dixit, S.N., et al., “Covalent Structure of Collagen: Amino Acid Sequence of α2-CB5 of Chick Skin Collagen Containing the Animal Collagenase Cleavage Site,”Biochemistry, 18:3416-3422 (1979).
Dakkak, et al., “Modifications de l'hydroxyprolinurie peptidique au cours de la maladie de Paget et des ostéomes,”Ann. Biol. Clin. 37:195-200 (1979).
Whittle, et al., “Biochemical investigation of possible lesions in human aorta that predispose to dissecting aneurysms: pyridinoline crosslinks,”Cardiovascular Research21:161-168 (1987).
Gunja-Smith, Z., “An Enzyme-Linked Immunosorbent Assay to Quantitate the Elastin Crosslink Desmosine in Tissue and Urine Samples,”Analytical Biochemistry147:258-264 (1985).
Schuppan, et al., “Radioimmunoassay for the Carboxy-terminal Cross-linking Domain of Type IV (Basement Membrane) Procollagen in Body Fluids,”J. Clin. Invest. 78:241-248 (Jul. 1986).
Eyre, D., “Collagen Cross-Linking Amino Acids,” In:Methods in Enzymology, vol. 144, pp. 115-139, Academic Press, Inc., 1987.
Eyre, et al., “Identification of urinary peptides derived from cross-linking sites in bone collagen in Paget's Disease,”Journal of Bone and Mineral Research, 3, Supp. 1 (Jun. 1988).
Eyre, et al., “Reducible Crosslinks in Hydroxylysine-Deficient Collagens of a H
Christensen O'Connor Johnson & Kindness PLLC
Leary Louise N.
Washington Research Foundation
LandOfFree
Urinary assay for measuring bone resorption does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Urinary assay for measuring bone resorption, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urinary assay for measuring bone resorption will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3382488