Uricase and a method for the preparation thereof

Details Uricase and a method for the preparation thereof Uricase and a method for the preparation thereof

1989-08-09

1991-01-22

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Oxidoreductase

435 10, 435221, 435228, 435832, C12Q 162, C12N 954, C12N 980, C12N 906

Patent

active

049870769

ABSTRACT:
Different from conventional uricase products, the uricase of the present invention has outstandingly high thermal stability and is active in a wide range of pH from 5 to 10 for the oxidative decomposition of uric acid undertaken in clinical analysis. The uricase of the invention is produced microbiologically by a thermophilic microorganism belonging to the genus of Bacillus and especially named as Bacillus sp. TB-90 which is a novel species distinguishable from any of the microorganisms belonging to the genus of Bacillus.

REFERENCES:
patent: 3810820 (1974-05-01), Laboureur et al.
patent: 4753882 (1988-06-01), Takashio et al.
Kaltwasser, H., J. Bacteriology, vol. 104, pp. 780-786, (1971).
Analytical Biochemistry, 38, 65-84, (1970), J. L. Mahler, "A New Bacterial Uricase for Uric Acid Determination".

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