Uricase and a method for the preparation thereof

Details Uricase and a method for the preparation thereof Uricase and a method for the preparation thereof

1986-05-22

1989-11-21

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

4352536, 435832, 435 10, 435191, 4352525, C12N 120, C12N 980, C12N 906, C12N 122, C12R 107, C12Q 162

Patent

active

048822809

ABSTRACT:
Different from conventional uricase products, the uricase of the present invention has outstandingly high thermal stability and is active in a wide range of pH from 5 to 10 for the oxidative decomposition of uric acid undertaken in clinical analysis. The uricase of the invention is produced microbiologically by a thermophilic microorganism belonging to the genus of Bacillus and especially named as Bacillus sp. TB-90 which is a novel species distinguishable from any of the microorganisms belonging to the genus of Bacillus.

REFERENCES:
patent: 3810820 (1974-05-01), Laboureur et al.
patent: 4753882 (1988-05-01), Takashio et al.
Mahler, J. L., Analytical Biochemistry, vol. 38, pp. 65-84, (1970).

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