Ureylenethiophanes and their related compounds, and production t

Details Ureylenethiophanes and their related compounds, and production t Ureylenethiophanes and their related compounds, and production t

1975-08-05

1976-09-28

Love, Ethel G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260329AM, 2603321, 2603322R, 2603473, 2603474, C07D 4934

Patent

active

039831345

ABSTRACT:
Ureylenethiophanes and their related compounds of the formula: ##SPC1##
Having a cis-configuration on the ureylene or thioureylene juncture, which are useful as the intermediates in the synthesis of biologically active biotin and its related compounds, can be produced selectively by reacting the corresponding compounds of the formula: ##SPC2##
With isocyanates or isothiocyanates wherein R is a hydrogen atom, an alkyl group or an aralkyl group, R.sub.1 and R.sub.2 are each a hydrogen atom or an aliphatic hydrocarbon group bearing or not a carboxyl group or any other group convertible thereto at the terminal position, X is a halogen atom, Y is an oxygen atom or a sulfur atom and Z is an oxygen atom, a sulfur atom, a sulfinyl group or a sulfonyl group.

REFERENCES:
patent: 2489237 (1949-11-01), Goldberg et al.
patent: 2492373 (1949-12-01), Wood et al.
patent: 2506594 (1950-05-01), Hoffman

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