Urethanes and ureas that induce cytokine production

Details Urethanes and ureas that induce cytokine production Urethanes and ureas that induce cytokine production

1995-05-25

1997-08-19

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514 19, 514484, 514485, 514488, 514489, 514566, A61K 3127, A61K 3800, A61K 31195

Patent

active

056589450

ABSTRACT:
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

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Kolodziejczyk et al., Int. J. Peptide Protein Res., 39:382-387 (1992).
Nakajima et al., Arznein. Forsch./Drug Res., 41(I):60-64 (1991).

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