Urethanes and ureas that induce cytokine production

Details Urethanes and ureas that induce cytokine production Urethanes and ureas that induce cytokine production

1994-03-14

1996-08-13

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514 19, 514484, 514488, 514489, 514566, A61K 3800, A61K 3127, A61K 31195

Patent

active

055456626

ABSTRACT:
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

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Azuma et al., Int. J. Immnopharmac., 14: 487-496 (1992) "Review: Inducer of Cytokines in vivo: Overview of Field and Romurtide Experience."
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Nakamura et al., Agric. Biol. Chem. 48(10): 2579-2580 (1984), "Induction of Colony-stimulating Factor (CSF) by FK-156 and its Synthetic Derivative, FK-565."
Dezelee et al., Biochemistry, 9: 823-831 (1970) "Stereo-Specific Synthesis of Meso-Diaminopimelic Acid peptides."
Ellouz et al., Biochem. Biophys. Res. Comm., 59: 1317-1325 (1974), "Minimal Structural Requirement for Adjuvant Activity of Bacterial Peptidoglycan Derivatives."
Kolodziejczyk et al., Int. J. Peptide Protein Res., 39: 382-387 (1992), "New Convenient Synthesis of Immunostimulating Peptides Containing Meso-diaminopimelic acid."
Izumi et al., J. Antibiotics, 36(5): 566-574 (1983), "Antitumor Effects of novel Immunoactive Peptides."
Nakajima et al., Arzneim. Forsch./Drug Res., 41(1): 60-64 (1991), "Stimulatory Effect of Romurtide on Hematopoiesis in Monkeys."5
Milowsky; Arnold S.

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