Urethanes and ureas that induce cytokine production

Details Urethanes and ureas that induce cytokine production Urethanes and ureas that induce cytokine production

1993-05-12

1994-05-17

Shippen, Michael L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514 19, 514484, 514485, 514488, 514489, 514566, 544 584, 544168, 544224, 544237, 544335, 544355, 544383, 544390, 544406, 546146, 546147, 546255, 546262, 546496, 562439, 562560, 564 47, 564 57, 564 59, 548127, 548136, 548200, 548214, 548236, 548248, 548253, 5483335, 5483741, 548495, 548530, 549 72, 549365, 549366, 549487, 560 25, 560 28, 560 29, 560 32, 560 33, 560 34, 560115, 560158, 560159, A61K 3700, C07C26100

Patent

active

053128311

ABSTRACT:
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

REFERENCES:
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patent: 4349466 (1982-09-01), Kitaura et al.
patent: 4666890 (1987-05-01), Kitaura et al.
Dezelee et al., Biochemistry, 9: 823-831 (1970) "Stereo-Specific Synthesis of Meso-Diaminopimelic Acid Peptides".
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Kolodziejczyk et al., Int. J. Peptide Protein Res., 39: 382-387 (1992), "New Convenient Synthesis of Immunostimulating Peptides Containing Meso-diaminopimelic acid".
Azuma et al., Int. J. Immunopharmac., 14: 487-496 (1992) "Review: Inducer of Cytokines in vivo: Overview of Field and Romurtide Experience".
Hemmi et al., Tet. Lttrs., 23: 693-696 (1982) "An Efficient Method for Selective Amino Acid Protection of Meso-2,2'-Diaminocarboxylic acid".
Nakamura et al., Agric. Biol. Chem. 48(10): 2579-2580 (1984), "Induction of Colony-stimulating Factor (CSF) by FK-156 and Its Synthetic Derivative, FK-565".
Izumi et al., J. Antibiotics, 36(5): 566-574 (1983), "Antitumor Effects of Novel Immunoactive Peptides".
Nakajima et al., Arzneim. Forsch./Drug Res., 41(I): 60-64 (1991), "Stimulatory Effect of Romurtide on Hematopoiesis in Monkeys".

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