Urethanes and ureas that induce cytokine production

Details Urethanes and ureas that induce cytokine production Urethanes and ureas that induce cytokine production

1995-05-25

1997-02-11

Shippen, Michael L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 22, 560 28, 560 29, 560 32, 560 33, 560 34, 560115, 560158, 562439, 562560, 564 47, 564 57, 564 59, C07C26100

Patent

active

056022751

ABSTRACT:
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

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Kolodziejczyk et al., Int. J. Peptide Protein Res., 39:382-387 (1992).
Nakajima et al., Arznein. Forsch./Drug Res., 41(I):60-64 (1991).

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