Urethanes and ureas that enhance the growth of bone marrow proge

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai

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514 19, 514484, 514485, 514488, 514489, 514566, A61K 3700, A61K 3800

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active

056166125

ABSTRACT:
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

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Kolodziejczyk et al., Int. J. Peptide Protein Res., 39:382-387 (1992).
Nakajima et al., Arznein. Forsch./Drug Res., 41(I):60-64 (1991).

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