Urethanes and ureas that enhance the growth of bone marrow proge

Details Urethanes and ureas that enhance the growth of bone marrow proge Urethanes and ureas that enhance the growth of bone marrow proge

1995-05-25

1997-04-01

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514 19, 514484, 514485, 514488, 514489, 514566, A61K 3700, A61K 3800

Patent

active

056166125

ABSTRACT:
The invention relates to novel ureas and urethanes of Formula I: ##STR1## which stimulate cytokine production and may be used to accelerate recovery from neutropenia accompanying radio- or chemotherapy, bone marrow transplantation, or infections. Compounds in the invention or pharmaceutical compositions employing these compounds may be useful in the treatment of cancer, AIDS, aplastic anemia, myelodysplastic syndrome, and infectious diseases, and in the enhancement of immune response.

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Azuma et al., Int. J. Immunopharmac., 14:487-496 (1992).
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Ellouz et al., Biochem. Biophys. Res. Comm., 59:1317-1325 (1974).
Kolodziejczyk et al., Int. J. Peptide Protein Res., 39:382-387 (1992).
Nakajima et al., Arznein. Forsch./Drug Res., 41(I):60-64 (1991).

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