Urethane derivatives of 2-phenyl-4(3H)-quinazolones

Details Urethane derivatives of 2-phenyl-4(3H)-quinazolones Urethane derivatives of 2-phenyl-4(3H)-quinazolones

1974-06-07

1976-01-13

Schenkman, Leonard

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602565R, 424251, C07D23900

Patent

active

039324095

ABSTRACT:
2-Phenyl-4(3H)-quinazolones bearing a urethane or thiourethane group on the 2-phenyl substituent, a second urethane or thiourethane group on the benzo ring of the quinazolone nucleus and an alkyl, cycloalkyl or phenyl group in the 3-position are prepared by treating the corresponding bis-amino compound with an acid derivative or the corresponding bis(isocyanate) or bis(isothiocyanate) with an alcohol. The compounds, of which 2-[3'-(methoxycarbonylamino)-phenyl]-3-phenyl-6-methoxycarbonylamino-4-(3H )-quinazolone is a typical embodiment, are cytostatic agents.

REFERENCES:
patent: 3448109 (1969-06-01), Heusner et al.

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