Urethane-containing aminosteroid compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

552515, A61K 3156, C07J 4100

Patent

active

059227036

ABSTRACT:
Urethane-containing amino steroids having the general chemical formula: ##STR1## wherein a, b, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.

REFERENCES:
patent: 4325879 (1982-04-01), Jarreau et al.
patent: 4552868 (1985-11-01), Jarreau et al.
patent: 4584289 (1986-04-01), Jarreau et al.
patent: 4885280 (1989-12-01), Jarreau et al.
patent: 5144017 (1992-09-01), LaBella et al.
patent: 5175281 (1992-12-01), McCall et al.
DiBianco, R., et al., "A Comparison of Oral Milrinone, Digoxin, and their Combination in the Treatment of Patients with Chronic Heart Failure", 320 N. Engl. J. Med. 677 (1989).
Goodman and Gilman, The Pharmacological Basis of Therapeutics, Chapter 34, (8th Ed., 1990).
Nicklas, J. M. and Pitt, B., et al. (The SOLVID Investigators) "Effect of Enalapril on Survival in Patients with Reduced Left Ventrical Ejection Fractions and Congestive Heart Failure", 325(5) N. Engl. J. Med. 293 (1991).
Templeton, J. et al., "Synthesis of 20-Hydroxy-, 20-Amino-, and 20-Nitro-14-hydroxy-21-nor-5.beta., 14.beta.-pregnane C-3 Glycosides and Related Derivatives: Structure-Activity Relationships of Pregnanes That Bind to the Digitalis Receptor", 36 J. Med. Chem. 42-45 (1993).
Templeton, J. et al., "Synthesis of 20.alpha.- and 20.beta.-Acetamido, Amino, Nitro and Hydroxy Derivatives of 14-Hydroxy-5.beta., 14.beta.=pregnane 3.beta.-Glycosides: Pregnanes that Bind to the Digitalis Receptor", 1 J. Chem. Soc. Perkin Trans. 2503-2517 (1992).
Adeoti, S., et al., "Introduction of A 14.beta.-Nitrated Function Into The Steroid Ring To Prepare The Cardioactive Molecule, 14.beta.-Amino-5.beta.-Pregnane3.beta., 20.beta.-Diol, From Progesterone and Deoxycholic Acid", 45 (12), Tetradhedron 3717-3730 (1989) (English Translation).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Urethane-containing aminosteroid compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Urethane-containing aminosteroid compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urethane-containing aminosteroid compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2275878

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.