Urease-responsive delivery systems for diagnostic and therapeuti

Details Urease-responsive delivery systems for diagnostic and therapeuti Urease-responsive delivery systems for diagnostic and therapeuti

1998-01-29

2000-12-05

Dudash, Diana

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424499, 424492, 424456, 424486, 424487, 424488, 424 91, 424 92, 435 4, 435 12, 514152, 514198, A61K 914, A61K 950

Patent

active

061563463

ABSTRACT:
A delivery system that releases a diagnostic marker or therapeutic agent in a manner sensitive to the concentration of urease in a physiological compartment, particularly the gastrointestinal tract, and methods of use.

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Zhao et al, J. Am. Chem. Soc; 112, 6627-6634, 1990.
Morrison & Boyd, Allyn and Bacon, Inc. Organic Chemistry fifth edditon, Chapter 23, p. 887, 1981.
Walsh et al, N Eng J Med; 333: 984-991, 1995.
Pawlak, D et al, Polish Journal of Chemistry; 68: 1067-1069, 1994.

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