Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1985-07-03
1987-06-09
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514788, 514970, A61K 3117, A61K 4700
Patent
active
046720782
ABSTRACT:
A pharmaceutical preparation containing 1 to 50% urea and 0.05 to 30% of a lactone is disclosed. A preferred lactone is gamma-butyrolactone which is preferably present in an amount of about 0.05 to 0.1 part by weight per 1 part by weight of urea. The lactone stabilizes the urea with respect to various parameters including changes in pH. The pharmaceutical preparation may be any preparation with stabilized urea such as a skin lotion or cream used to moisturize skin, or a post surgical preparation because urea aids in debridement, dissolves coagulum and promotes epithelialization. Alternatively the preparation may be an injectable solution used in the treatment for mobilization of edema fluid, as urea is used for an osmotic diuretic.
REFERENCES:
patent: 3666863 (1972-05-01), Swanbeck
patent: 4291062 (1981-09-01), Leigh et al.
Quick Timothy W.
Sakai Kirk
Maitner John J.
Miller Stephen I.
Nelson James R.
Schering-Plough Corporation
Waddell Frederick E.
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