Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1993-09-09
1995-11-28
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514912, A61K 3117
Patent
active
054708818
ABSTRACT:
A topical ophthalmic preparation utilizing a urea and/or urea derivative or mixtures thereof as the principle active ingredient within a range of about 0.01% by weight to about 30% by weight and a method of using the same. When applied to a mammalian eye affected with an abnormal ophthalmological surface problem resulting in epithelial cell loss, keratinization, and/or scarring, the present invention will heal epithelial defects, soften keratin, decrease scarring, enhance hydration, and have anti-mucolytic activity. The present invention provides a method for treating ocular conditions such as dryness, noninfectious keratitis, corneal or conjunctival epithelial irregularities, ocular scarring and subjective irritations.
REFERENCES:
patent: 4409205 (1983-10-01), Shively
Ashton H. et al., Therapeutics XIII Urea as a Topical Agent, Quarterly Review, BR J Dermatol 84:194, 1970.
Lars Hellgren and Kare Larsson, "On the Effect of Urea on Human Epidermis", Dermatologica 149:289-293 (1974).
Gunnar Swanbeck, "A New Treatment of Ichthyosis and Other Hyperkeratotic Conditions", Acta derm.-venerol. 48:123-127, 1968.
Jorn Hess Thaysen and Niels A. Thorn, "Excretion of Urea, Sodium, Potassium and Chloride in Human Tears", American Journal of Physiology 178:160-164, 1954.
W. P. Raab, "Uses of Urea in Cosmetology", Cosmetics and Toiletries, vol. 105, pp. 97-102 (May 1990).
Paritosh K. Banerjee, et al., "Topical Urea in Dermatology", Indian J. Dermatology, vol. 35, No. 1, Mar. 1990 48:123-127, 1968.
Toshiaki Nishihata, et al., "Combined Effect of Alcohol and Urea on the In Vitro Transport of Indomethacin across Rat Dorsal Skin", Journal of Pharmaceutical Sciences, vol. 79, No. 6, Jun. 1990.
The Merck Index, "An Encyclopedia of Chemicals, Drugs, and Biologicals", Eleventh Edition, pp. 44 and 1553 (1989).
Altwein, et al., "Effect of Urea Concentrations on the Solubility of the Isometric Monohydroxybenzoic Acids", Journal of Pharmaceutical Sciences, vol. 54, No. 4, pp. 603-606 (Apr. 1965).
American Hospital Formulary Service, 40:28 Diuretics, pp. 1362-1364 1987.
Gilbard, et al., "Morphologic Effect of Hypersmolarity on Rabbit Corneal Epithelium", Ophthalmology 91:1205-1212, 1984.
Socma Handbook, "Commercial Organic Chemical Names", p. 195 (1965).
Connors, et al., "Chemical Stability of Pharmaceuticals", a Handbook for Pharmacists, Second Edition, pp. 780-786 (1986).
Sigma, "Biochemicals Organic Compounds--Diagnostic Reagents", Order Form and Price List pp. 202, 1000-1001, (1994).
Aldrich Chemical Company, Inc., Order Form and Price List, 1992.
Sanford Bolton, "Interaction of Urea and Thiourea with Benzoic and Salicylic Acids", Journal of Pharmaceutical Science, vol. 52, No. 11, Nov. 1963, pp. 1071-1074.
Apple, et al., "Clinicopathologic Correlation of Ocular Disease", Second Edition, 1978, pp. 456-457.
Yanoff, et al., "Ocular Pathology", Second Edition, 1982, p. 318.
Embase Abstract by Opthamologica, 1979, (198-203) Danopoulos et al.
Charlton Judie F.
Schwab Ivan R.
Stuchell Robert M.
Fay Zohreh
West Virginia University Research Corporation
LandOfFree
Urea ophthalmic ointment and solution does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Urea ophthalmic ointment and solution, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urea ophthalmic ointment and solution will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2013983