Urea linker derivatives for use as PPAR modulators

Details Urea linker derivatives for use as PPAR modulators Urea linker derivatives for use as PPAR modulators

2006-01-10

2006-01-10

O'Sullivan, Peter (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S562000, C514S563000, C514S564000, C514S566000, C562S439000, C562S431000, C549S439000

Reexamination Certificate

active

06984661

ABSTRACT:
The present invention is directed to compounds of the structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof: Formula I (a) R1, R2 and R6 are each independently selected from the group consisting of hydrogen, C1-C8alkyl substituted C1-C8alkyl, aryl-C0-4-alkyl, substituted aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, substituted heteroaryl-C0-4-alkyl, C3-C6cycloalkylaryl-C0-2-alkyl, and substituted C3-C6cycloalkylaryl-C0-2-alkyl; (b) X is an optionally substituted C1-C5alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; (c) Y is C, O, S, NH or a single bond; and (d) E is selected from the group consisting of hydrogen, C(R3)(R4)A, A, (CH2)nCOOR19 and substituted (CH2)nCOOR19.

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