Urea inhibitors of MAP kinases

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C540S575000, C544S059000, C544S386000, C549S069000, C549S070000

Reexamination Certificate

active

07741479

ABSTRACT:
The present invention is directed to a compound having the formulawherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.

REFERENCES:
patent: 5569654 (1996-10-01), Armour et al.
patent: 5599930 (1997-02-01), Romero et al.
patent: 5696110 (1997-12-01), Bourrain et al.
patent: 5763437 (1998-06-01), Sato et al.
patent: 5942387 (1999-08-01), Hollinshead
patent: 6080763 (2000-06-01), Regan et al.
patent: 6187799 (2001-02-01), Wood et al.
patent: 6228881 (2001-05-01), Regan et al.
patent: 6242453 (2001-06-01), Cirillo et al.
patent: 6297381 (2001-10-01), Cirillo et al.
patent: 6329415 (2001-12-01), Cirillo et al.
patent: 6333325 (2001-12-01), Cirillo et al.
patent: 6358945 (2002-03-01), Breitfelder et al.
patent: 6372773 (2002-04-01), Regan
patent: 6492393 (2002-12-01), Breitfelder et al.
patent: 6506747 (2003-01-01), Betageri et al.
patent: 6506748 (2003-01-01), Hickey et al.
patent: 6525046 (2003-02-01), Cirillo et al.
patent: 6627629 (2003-09-01), Ko et al.
patent: 6656933 (2003-12-01), Hickey
patent: 2003/0069284 (2003-04-01), Keegan et al.
patent: 2003/0212070 (2003-11-01), Schwink et al.
patent: 2003/0225053 (2003-12-01), Gao et al.
patent: 2004/0122235 (2004-06-01), Polisetti et al.
patent: 2004/0259912 (2004-12-01), Matsumoto et al.
patent: 2005/0239841 (2005-10-01), Browning et al.
patent: 2006/0009453 (2006-01-01), Geuns-Meyer et al.
patent: 2006/0014761 (2006-01-01), Morgan et al.
patent: 2006/0069102 (2006-03-01), Leban et al.
patent: WO 98/52558 (1998-11-01), None
patent: WO 98/52559 (1998-11-01), None
patent: WO 99/32111 (1999-01-01), None
patent: WO 99/32110 (1999-07-01), None
patent: WO 99/32111 (1999-07-01), None
patent: WO 99/32463 (1999-07-01), None
patent: WO 00/41698 (2000-07-01), None
patent: WO 00/43384 (2000-07-01), None
patent: WO 00/55139 (2000-09-01), None
patent: WO 00/55152 (2000-09-01), None
patent: WO 00/55152 (2000-09-01), None
patent: WO 01/36403 (2001-05-01), None
patent: 02/14311 (2002-02-01), None
patent: WO 02/083628 (2002-10-01), None
patent: WO 02/083642 (2002-10-01), None
patent: WO 02/085859 (2002-10-01), None
patent: WO 02/092576 (2002-11-01), None
patent: WO 02/096876 (2002-12-01), None
patent: WO 02/098869 (2002-12-01), None
patent: WO 03/005999 (2003-01-01), None
patent: WO 03/049742 (2003-06-01), None
patent: WO 03/068229 (2003-08-01), None
patent: WO 03/068746 (2003-08-01), None
patent: WO 2004/056827 (2004-07-01), None
patent: WO 2004/060305 (2004-07-01), None
patent: WO 2004/060305 (2004-07-01), None
patent: WO 2004/060306 (2004-07-01), None
patent: WO 2004/060306 (2004-07-01), None
patent: WO 2004/061084 (2004-07-01), None
patent: WO 2004/061084 (2004-07-01), None
patent: WO 2004/089929 (2004-10-01), None
patent: WO 2004/111009 (2004-12-01), None
patent: WO 2005/014554 (2005-02-01), None
patent: WO 2005/023761 (2005-03-01), None
patent: WO 2005/023761 (2005-03-01), None
patent: 2006/018662 (2006-02-01), None
patent: 2006/062982 (2006-06-01), None
patent: 2006/078610 (2006-07-01), None
Attanasi, O.A., et al., “Conjugated Azoalkenes. Part 12. Synthesis of New 1-Amino0-3-cyanopyrrole, 1,2-Diaminopyrrole and Pyrrolo[2,3-b]pyrrole Derivatives by Reaction of Some Conjugated Azoalkenes with Activated Nitriles,”J. Chem. Soc. Perkin Trans.1:1009-1014, Journal of the Chemical Society (1992).
Burak, K., and Machon, Z., “Synthesis of isothiazole derivatives with potential biological activity,”Pharmazie47:492-495, Govi-Verlag, Pharmazeutischer Verlag GmbH (1992).
Watt, A.P., et al., “Use of chiral liquid chromatography—tandom mass spectrometry to investigate the metabolism of racemic cholecystokinin-B antagonists,”J. Chromatogr. A896:217-227, Elsevier Science B.V. (2000).
Search results of STN CHEMCATS Database, May 15, 2006 (American Chemical Society).
P38 Drug Discovery Program, Locus Pharmaceuticals, Nov. 2, 2004.
Wilson, K.P., et al., “Crystal Structure of p38 Mitogen-activated Protein Kinase,”J. Biol. Chem.44:27696-27700, American Society for Biochemistry & Molecular Biology, Inc. (1996).
Co-pending U.S. Appl. No. 11/295,433, inventors Michelotti, E.L., et al., filed Dec. 7, 2005 (Not Published).
Co-pending U.S. Appl. No. 11/649,363, inventors Michelotti, E.L., et al., filed Jan. 4, 2007 (Not Published).
Form PCT/ISA/220, Written Opinion and ISR from PCT/US2009/053959, Jan. 12, 2010.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Urea inhibitors of MAP kinases does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Urea inhibitors of MAP kinases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Urea inhibitors of MAP kinases will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4242577

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.