Urea derivatives and their use as ACAT inhibitors

Details Urea derivatives and their use as ACAT inhibitors Urea derivatives and their use as ACAT inhibitors

1994-09-29

1996-11-19

Tsang, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544224, 544349, 544382, 544390, 546332, 546285, 546306, 514357, 514597, 514598, 514249, 514255, 514353, 564 50, 564 51, 564 52, C07D21126, C07D21336, A61K 31445, A61K 3144

Patent

active

055763359

ABSTRACT:
Urea derivatives of formula (1) ##STR1## wherein the valuable groups are as defined in the specification, which possess both an ACAT inhibitory activity and an antioxidative activity. Those derivatives are useful in the prophylaxis and treatment of hypercholesterolemia and atherosclerosis.

REFERENCES:
patent: 3660486 (1972-05-01), Thiele et al.
patent: 5116848 (1992-05-01), Trivedi
patent: 5214206 (1993-05-01), Picard et al.
patent: 5258405 (1993-11-01), Ito et al.
Morel, D., et al, "Endothelial and Smooth Muscles . . . ", Arteriosclerosis, 4, 357-364 (1984) Month of publication not provided.
Kita, T., et al, "Probucol prevents the progression . . . ", Proc. Natl. Acad. Sci., USA 84, 5928-5931 (1987) Month of publication not provided.
Largis, E. E., et al, J. Lipid Research 30, 681-690 (1989), "CL 277,082: a novel inhibitor . . . " Month of publication not provided.
Natori, K., et al, "Mechanism of the Inhibition of Cholesterol . . . "Japan J. Pharm., 42, 517-523 (1986) Month of publication not provided.
Mao, S. J. T., et al, "Antioxidant Activity of Probucol . . . " J. Med. Chem., 34, 298-302 (1991) Month of publication not provided.
Kornev, K. A. et al. Chemical Abstract Service, Abstract No. 70:67779 (1968).
Shibasaki et al. Chemical Abstract Service, Abstract No. 69:86908 (1968).
Swinyard, E. A. et al. Remington's Pharmaceutical Sciences, ed. Gennaro, A. R. et al. (Mack Pub. Co., Easton) pp. 1286-1304 (1990).

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