Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-11-13
1998-09-15
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514241, 514242, 514252, 544179, 544180, 544182, 544212, 544238, 544295, 544357, 544360, 544364, 544366, 544370, 544371, 544372, 544393, 544400, A61K 31495, A61K 3153, C07D24102, C07D40302
Patent
active
058078606
ABSTRACT:
A compound represented by formula (I) and a salt thereof, and a hydrate and solvate thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 represent independently, for example, hydrogen atom, hydroxyl group, or C.sub.1-3 alkoxy group; R.sub.4 represents, for example, C.sub.1-7 alkyl group or C.sub.3-7 cycloalkyl group; R.sub.5 and R.sub.6 represent independently, for example, hydrogen atom or C.sub.1-3 alkyl group; Y represents C.sub.1-3 alkyl group, a heterocyclic group containing 1 to 4 nitrogen atoms and 5 or 6 ring-membered atoms, or C.sub.6-10 aryl group; k represents an integer of 1 to 3; and l represents an integer of 2 to 4. These urea compounds have excellent inhibitory activities against ACAT and are useful as active ingredients of medicines for preventive and/or therapeutic treatment of hyperlipemia and atherosclerosis.
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Kimura et al., J. Med. Chem., vol. 36 (1993) pp. 1630-1640.
Kimura et al., J. Med. Chem., vol. 36 (1993) pp. 1641-1653.
Inoue Shinya
Kawai Mizue
Mitsuka Masayuki
Suzuki Kazuo
Takahashi Chizuko
Coleman Brenda
Mitsubishi Chemical Corporation
Shah Mukund J.
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