Urea and urethane derivatives as integrin inhibitors

Details Urea and urethane derivatives as integrin inhibitors Urea and urethane derivatives as integrin inhibitors

2006-11-14

2006-11-14

Richter, Johann (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S019000, C560S035000, C560S155000, C560S168000, C560S169000, C562S433000, C562S553000, C562S561000, C564S123000, C564S161000, C564S163000, C564S169000, C564S225000, C564S244000

Reexamination Certificate

active

07135587

ABSTRACT:
Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent Claim1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart disease, arteriosclerosis, inflammation, tumors. Osteoporosis, infections and restenosis after angioplasty or in pathological processes maintained or propagated by antiogenesis.

REFERENCES:
patent: 6645991 (2003-11-01), Jonczyk et al.
patent: WO 9622966 (1996-08-01), None
patent: WO 9952493 (1999-10-01), None
patent: WO 0064866 (2000-11-01), None

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